effect allele的概念也类似,就是我们想要研究其对疾病或表型效应的allele,所以通常是对表型或疾病有贡献的allele,关联检验结果中effect一栏指的就是effect allele的效应。 目前遗传统计学软件中除了以上的allele区分外,还经常使用A1,A2等表述方式, 但只要理解了以上概念后,我们在分辨allele时就能得心应手了。 参考: ma...
Background: The Apolipoprotein E (ApoE) ϵ4 allele is strongly linked with Alzheimer's disease (AD) but is also becoming recognized as disease modifier in other neurological disorders. The effect of the ApoE ϵ4 allele on brain atrophy in frontotemporal dementia (FTD) has not been clarified...