Vitamin D deficiency is a candidate risk factor for osteoporosis, characterized by decreased bone mineral density (BMD). We performed this two-sample Mendelian randomization (MR) analysis to investigate the causal effect of vitamin D on BMD. We extracted
Dose-dependent association of apolipoprotein E allele epsilon 4 with late-onset, sporadic Alzheimer's disease. We examined the apolipoprotein E (apo E) genotypes in 47 patients with late-onset sporadic Alzheimer's disease (mean age at onset +/- standard deviation, 7... T Yoshizawa,K Yamakawa...
This paper announced the first whole-genome sequence of a dog, the Boxer, together with a description of unique elements within the canine genome and predictions of ancestral sample size and SNP density needed for whole-genome association studies. Article CAS PubMed Google Scholar Boyko, A. R...
transplantation (allo-HCT) versus chemotherapy in first complete remission for patients with cytogenetically intermediate-risk acute myeloid leukemia, depending on the presence or absence of FLT3-internal tandem duplication (ITD), nucleophosmin (NPM1), and CCAAT/enhancer binding protein alpha (CEBPA) ...
The percentage of sites with BOP was significantly higher in IL-1RN2+ compared to IL-1RN2 CP patients ( = 0.022).These results suggest that IL-1RN2 allele positivity is associated with periodontal disease in a Turkish population.关键词: Pathogenesis Chronic periodontitis Aggressive periodontitis IL...
(n=69) meeting the American Heart Association guidelines of 7.5 metabolic equivalent (MET) hours/week of exercise showed significantly lower PiB(The Pittsburgh compound B, which is the analogue of thioflavin T, is the most commonly used tracer for amyloid imaging)binding and higher levels of A...
Odds ratio (OR) and 95% confidence interval (CI) were used to investigate the strength of the association. The meta-analysis revealed no association between the IL1B (2511), (231), (13954) polymorphisms and COPD risk. However, stratification by ethnicity indicated that the T allele carriers...
Despite its disorganized molecular appearance, our data point to a highly controlled equilibrium between counteracting repressors within extra-embryonic cells, one that can seemingly persist indefinitely without bistable features typically seen for embryonic forms of epigenetic regulation....
Urinary pyridinoline levels were significantly elevated in those with the risk allele ( P < 0.05). Conclusion These data support the findings that the COL1A1 gene polymorphism is associated with low BMD and fracture risk, and suggest a possible physiologic effect on total body turnover of type ...
The OR for delirium in the meta-analysis was 1.6 (95% CI: 0.9–2.7) of σ4 carriers compared with non-σ4 carriers. This study and meta-analysis suggest an association between delirium and the APOE σ4 allele. 展开 关键词: Delirium apolipoprotein E epsilon 4 allele cognitive impairment ...