Lenti-X lentiviral vector systems with EF-1 alpha promoters allow you to achieve robust, constitutive, long-term expression of your gene of interest in cell types in which CMV promoters are often silenced, such as hematopoietic and stem cells. The EF-1 alpha promoter, which offers a broad...
Babazadeh, R., et al. (2011). "The Ashbya gossypii EF-1alpha promoter of the ubiquitously used MX cassettes is toxic to Saccharomyces cerevisiae." FEBS Lett 585(24): 3907-13.Babazadeh R, Jafari SM, Zackrisson M, et al. The Ashbya gossypii EF-1α promoter of the ubiquitously used MX...
In bacteria, the resistance gene is expressed from the constitutive E. coli EM7 promoter. In mammalian cells, the resistance gene is transcribed from the rat EF-1α promoter as a polycistronic mRNA and translated via the FMDV IRES. • EF1 pAnis a strong polyadenylation signal. ...
A hybrid promoter for recombinant expression of proteins of interest is disclosed that combines a mCMV enhancer sequence with a rat EF-1alpha intron sequen... JT Mcgrew,PS Smitdt,EC Ong 被引量: 0发表: 2019年 Translational Management - Research outputs - DTU Orbit (04/02/2019) / Arylalkyl...
自GLP-1被发现以来,它已然成为一种“多面手”激素——一个接一个代谢功能被人们发现,远远超出了其作为肠促胰素的经典定义。GLP-1的众多有益的多靶点作用使其逐渐成为更多新兴的治疗领域如脂肪肝、肥胖和神经退行性疾病等的冉冉之“星”药物。回归糖尿病...
Consequently, targeting of the efhd1 promoter by Suz12 should lead to decreased or no expression of EFhd1. Conclusions Calcium binding proteins of the EF-hand are involved in all aspects of cellular functions. EFhd2 and EFhd1 are two related EF-hand containing adaptor proteins with a similar...
Structures of the promoter-bound respiratory syncytial virus polymerase 启动子结合的呼吸道合胞病毒聚合酶的结构 (导读 阿金)呼吸道合胞病毒(RSV)聚合酶是多功能RNA依赖性RNA聚合酶,将RNA基因组转录成10个病毒mRNA,复制全长病毒基因组和抗基因组RNA。本研究报告了R...
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Here we identified the gluconeogenic enzyme fructose-1,6-bisphosphatase 1 (FBP1) as a p53 target that is elevated in senescent-like MASH hepatocytes but suppressed through promoter hypermethylation and proteasomal degradation in most human HCCs. FBP1 first declines in metabolically stressed premalignant...
An enhancer element 6 kb upstream of the mouse HNF4α1 promoter is activated by glucocorticoids and liver-enriched transcription factors We have characterized a 700 bp enhancer element around -6 kb relative to the HNF4alpha1 transcription start. This element increases activity and confers gl... ...