Recent advances in base editing have created an exciting opportunity to precisely correct disease-causing mutations. However, the large size of base editors and their inherited off-target activities pose challenges for in vivo base editing. Moreover, the
(including those with simultaneous editing of all six alleles), the transmission rates were 100%; for the majority of the heterozygous mutants, Mendelian segregation occurred (homozygote/heterozygote/wild type (WT): 1:2:1;Supplementary Table 5). As anticipated, all the T1 individuals were ...
Melchinger AE, Winter M, Mi X, et al. Controlling misclassification rates in identification of haploid seeds from induction crosses in maize with high-oil inducers. Crop Sci. 2015;55(3):1076–1086. (Open in a new window)Web of Science ®(Open in a new window)Google Scholar ...
Box and whisker plots showing comparative distribution of (a) substitution rates of non-synonymous over synonymous site (dN/dS) and (b) estimated time of gene duplication (MYA) in putative paralogues and orthologues ofLusHSFs. The top of the box or coloured region represents the 3rd quartile (...
In this section, as a preliminary validation, we verify the accuracy of the proposed model that predicts post scores representing engagement rates on social media from the image and text. Section 4.1 and Section 4.2 provide validation settings and results, respectively. 4.1. Validation Settings In ...