The dystrophin-associated protein complex (DAPC) comprises several proteins whose ultimate role is to connect the F-actin cytoskeleton of the muscular fibers with the laminin of the extracellular matrix. From: Biochimica et Biophysica Acta (BBA) - General Subjects, 2014 ...
The dystrophin-associated protein complex (DAPC) is composed of proteins that are highly expressed along the sarcolemma. The DAPC provides a mechanical link between the intracellular cytoskeleton and extracellular matrix, as well as a signal transduction apparatus from the periphery to the interior of...
Fig. 5.7. Localization of muscle membrane protein: the cysteine-rich and C-terminal domains of dystrophin are linked with a complex of at least six proteins, called the dystrophin-associated glycoproteins (DAGs) or dystrophin-associated proteins (DAPs) or dystrophin–glycoprotein complexes (DGC). ...
The dystrophin glycoprotein complex (DGC) has a crucial role in maintaining cell membrane stability and integrity by connecting the intracellular cytoskeleton with the surrounding extracellular matrix1–3. Dysfunction of dystrophin and its associated pro
Although α-dystrobrevin (DB) is assembled into the dystrophin-associated protein complex, which is central to cytoskeletal organization, it has also been found in the nucleus. Here we delineate the nuclear import pathway responsible for nuclear targeting of α-DB for the first time, together ...
The dystrophin glycoprotein complex (DGC) has a crucial role in maintaining cell membrane stability and integrity by connecting the intracellular cytoskeleton with the surrounding extracellular matrix1–3. Dysfunction of dystrophin and its associated pro
The dystrophin-associated protein complex (DAPC) plays a critical role in maintaining the structural integrity of the sarcolemma of skeletal muscle. In addition, several regulatory molecules, including neuronal nitric oxide synthase, are localized to the DAPC through the syntrophin family of adaptor ...
Similar to Dp71, Dp40 contains part of the WW domain, which provides the main binding site to β-dystroglycan (β-DG), a component of the dystrophin-associated protein complex (DAPC), as well as the EF-hand motifs and the ZZ domain involved in Ca2+ binding and transport to the ...
Thousands of recessive genetic mutations have been identified in the X-linked DMD gene [5], which encodes the dystrophin protein [6], a component of the transmembrane dystrophin-associated protein complex (DAPC) in all (cardiac, skeletal, and smooth) muscle cells [7,8,9]. The chronic ...
We recently discovered that α_1D-ARs form a "signalosome" with multiple members of the dystrophin-associated protein complex (DAPC) to become functionally expressed at the plasma membrane and bind ligands. However, the molecular mechanism by which the DAPC imparts functionality to the α_1D-AR...