Mdivi-1是一个具有选择性和细胞穿膜性的线粒体分裂抑制剂,抑制了DRP1(发动蛋白相关GTP酶)和Dynamin I (Dnm1)的IC50为1-10 μM。 靶点(IC50 & Targe) Dnm1 GTPase,1μM-10μM 体外研究 Mdivi-1是一个可以穿越细胞膜的喹唑酮类化合物,抑制了酵母的Dnm1和人源的Drp1分裂DRPs(发动蛋白相关GTP酶),并且高...
Mitochondrial fission is mediated by dynamin-related protein 1 (Drp1) and its adapter proteins, including mitochondrial fission protein 1 (Fis1) and mitochondrial fission factor (Mff). Drp1 is a cytosolic protein, which on activation, translocates to the outer mitochondrial membrane and docks with ...
We have previously demonstrated a therapeutic effect of peptide P110, a 7-amino acid peptide representing a homology sequence between dynamin-related protein 1 (Drp1) and Fission 1 (Fis1) [21], in reducing pathological mitochondrial dysfunction in multiple neurodegenerative diseases [20, 22,23,24...
Dynasore (Dynamin Inhibitor I) 是一种可渗透细胞的化学物质,可逆且非竞争性地抑制 dynamin 1/2 的 GTPase 活性。 它还抑制线粒体动力蛋白 Drp1,对其他小 GTPase 没有影响。 规格价格库存数量 1 mg ¥ 163 现货 5 mg ¥ 359 现货 10 mg
Though the combined effect of cisplatin and mdivi-1 is not dependent on mitochondrial fission protein Drp1, mitochondria do play a significant role in the rapid execution of apoptosis triggered by this combination. Highly uncoupled mitochondria, increased generation of reactive oxygen species (ROS) and...