Dynamin-Related Protein 1 (Drp1), a large GTPase of the dynamin superfamily, is required for mitochondrial fission in healthy and apoptotic cells. Drp1 act... I Bustillo-Zabalbeitia,S Montessuit,E Raemy,... - 《Plos One》 被引量: 80发表: 2014年 Dynamin-Related Protein-1 Controls Fusion...
Mdivi-1是一个具有选择性和细胞穿膜性的线粒体分裂抑制剂,抑制了DRP1(发动蛋白相关GTP酶)和Dynamin I (Dnm1)的IC50为1-10 μM。 靶点(IC50 & Targe) Dnm1 GTPase,1μM-10μM 体外研究 Mdivi-1是一个可以穿越细胞膜的喹唑酮类化合物,抑制了酵母的Dnm1和人源的Drp1分裂DRPs(发动蛋白相关GTP酶),并且高...
Though the combined effect of cisplatin and mdivi-1 is not dependent on mitochondrial fission protein Drp1, mitochondria do play a significant role in the rapid execution of apoptosis triggered by this combination. Highly uncoupled mitochondria, increased generation of reactive oxygen species (ROS) and...