Dynamin-related protein 1 (Drp1) is essential for mitochondrial and peroxisomal fission. Recent studies propose that Drp1 does not sever but rather constricts mitochondrial membranes allowing dynamin 2 (Dnm2) to execute final scission. Here, we report that unlike Drp1, Dnm2 is dispensable for ...
Recent studies have demonstrated that dynamin-related protein 1 (Drp1), a mitochondrial fission protein, mediates mitochondria-dependent apoptosis through mitochondrial division. However, little is known about the mechanism by which Drp1 modulates apoptosis in response to chlorpyrifos (CPF)-induced toxicity...
dynamin-related protein-1 (Drp1), thereby decreasing Drp1 accumulation in mitochondria and Drp1-mediated activation of the mitochondrial fission program. We also found that p53 transcriptionally downregulates miR-499 expression. Our data reveal a role for miR-499 in regulating the mitochondrial fission ...
Bioinformatics technology was used to analyze the expression level of dynamin-related protein 1 (DRP1), a key protein of mitochondrial division. The effects of DRP1 and DRP1 inhibitor (mdivi-1) on the proliferation and migration of liver cancer cells BEL-7402 were observed using cell counting kit...
Mdivi-1, 98%, a selective dynamin-related protein 1 (Drp1) inhibitor 品牌: J&K 产品编号: 1517233 CAS: 338967-87-6 分子式: C15H10Cl2N2O2S 分子量: 353.22 纯度: 98% 包装库存价格 5MG 上海: 1 ¥380 10MG 上海: 1 ¥610 1G 期货: 4~6 Weeks ¥43005 我的购物车推荐产品 4,4'...
Sharp WW (2014) Dynamin related protein 1 (Drp1) as a therapeutic target in cardiac arrest. J Mol Med. : 10.1007/s00109-015-1257-3Sharp WW (2014) Dynamin related protein 1 (Drp1) as a therapeutic target in cardiac arrest. J Mol Med. doi:10.1007/s00109-015-1257-3...
The large cytosolic GTPase, dynamin-related protein 1 (Drp1), mediates both physiological and pathological mitochondrial fission. Cell stress triggers Drp1 binding to mitochondrial Fis1 and subsequently, mitochondrial fragmentation, ROS production, metab
We have previously demonstrated a therapeutic effect of peptide P110, a 7-amino acid peptide representing a homology sequence between dynamin-related protein 1 (Drp1) and Fission 1 (Fis1) [21], in reducing pathological mitochondrial dysfunction in multiple neurodegenerative diseases [20, 22,23,24...
(HUVECs), which accelerated dynamin-related protein 1 (Drp1)-mediated mitochondrial fission. Silencing MiD49/51 reduced atherosclerotic plaque size, increased collagen content, and decreased the IL-8-induced adhesion and proliferation of HUVECs. MiD51 upregulation resulted from decreased microRNA (miR...
However, the enhanced cellular sensitivity to cisplatin by mdivi-1 was also observed in Drp1 (a mitochondrial fission protein and the supposed target of mdivi-1) knockout MEF cells, indicating Drp1-independent roles of these compounds in overcoming platinum drug resistance. The combination of ...