Drp1线粒体阿尔茨海默病(AD)已成为威胁老年人生活的一种常见病,对老年人的生活质量有着严重的影响,目前尚无有效地防治方法。最新研究发现在阿尔茨海默病的病理发生中,神经细胞伴有显著的线粒体代谢紊乱和动态变化的异常,其中动力相关蛋白1(Drp1)是参与线粒体动态变化的关键分子。深入研究阿尔茨海默病中线粒体动态...
Dynamin-related protein 1 (Drp1) is essential for mitochondrial and peroxisomal fission. Recent studies propose that Drp1 does not sever but rather constricts mitochondrial membranes allowing dynamin 2 (Dnm2) to execute final scission. Here, we report that unlike Drp1, Dnm2 is dispensable for ...
Dynamin-Related Protein 1 (Drp1), a large GTPase of the dynamin superfamily, is required for mitochondrial fission in healthy and apoptotic cells. Drp1 act... I Bustillo-Zabalbeitia,S Montessuit,E Raemy,... - 《Plos One》 被引量: 80发表: 2014年 Dynamin-Related Protein-1 Controls Fusion...
Dynamin-related protein 1 (DRP1), an 80 kDa GTPase, is involved in mitochondrial fission and anticancer drug-mediated cytotoxicity, which implicate an association with disease progression of cancer. In this study we investigated the prognostic value o
Mitochondrial fission is mainly controlled by the dynamin-related protein 1 (Drp1). Recent research revealed that various pathological conditions, such as cancer, obesity, diabetes, cardiovascular diseases, alcohol injury, and neurodegenerative disorders such as Huntington's disease (HD), Alzheimer's ...
Mdivi-1是一个可以穿越细胞膜的喹唑酮类化合物,抑制了酵母的Dnm1和人源的Drp1分裂DRPs(发动蛋白相关GTP酶),并且高效可逆的诱导线粒体融合进一个巢样的结构。细胞外的研究表明mdivi-1通过变构调节阻断了Dnm1的ATP酶活性(IC50<10μM)和自组装。在HeLa细胞和细胞外鼠源肝细胞线粒体配置液中,Mdivi-1有效地分别...
Aims: Dynamin-related protein1 (Drp1) is a large GTPase that mediates mitochondrial fission. We recently reported in Alzheimer's disease (AD) that S-nitrosylation of Drp1 (forming S-nitroso [SNO]-Drp1) results in GTPase hyperactivity and mitochondrial fragmentation, thus impairing bioenergetics and...
Sharp WW (2014) Dynamin related protein 1 (Drp1) as a therapeutic target in cardiac arrest. J Mol Med. : 10.1007/s00109-015-1257-3Sharp WW (2014) Dynamin related protein 1 (Drp1) as a therapeutic target in cardiac arrest. J Mol Med. doi:10.1007/s00109-015-1257-3...
Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduc... Mitochondrial fission, regulated by dynamin-related protein-1 (Drp1), is a newly recognized determinant of mitochondrial function, but its contribu...
The activity of the mitochondrial fission enzyme dynamin-related protein 1 (Drp1) is finely tuned by several post-translational modifications. Phosphorylation of Ser-656 by cAMP-dependent protein kinase (PKA) inhibits Drp1, whereas dephosphorylation by a mitochondrial protein phosphatase 2A isoform and ...