Dynamin-related protein 1属于动力蛋白GTP酶超家族,是线粒体分裂体系的组成成分,在线粒体分裂中具有重要作用。在不同物种中,dynamin—related protein 1在与多种分子相互作用后,可以定位于线粒体并组装成高级结构,引起膜的收缩和分裂。Dynamin—relatedp rotein 1功能的消失会增强线粒体的融合和线粒体之间的连通性...
Dynamin-Related Protein 1 (Drp1), a large GTPase of the dynamin superfamily, is required for mitochondrial fission in healthy and apoptotic cells. Drp1 act... I Bustillo-Zabalbeitia,S Montessuit,E Raemy,... - 《Plos One》 被引量: 80发表: 2014年 Dynamin-Related Protein-1 Controls Fusion...
Dynamin-related protein 1 (DRP1), an 80 kDa GTPase, is involved in mitochondrial fission and anticancer drug-mediated cytotoxicity, which implicate an association with disease progression of cancer. In this study we investigated the prognostic value o
Mdivi-1是一个具有选择性和细胞穿膜性的线粒体分裂抑制剂,抑制了DRP1(发动蛋白相关GTP酶)和Dynamin I (Dnm1)的IC50为1-10 μM。 靶点(IC50 & Targe) Dnm1 GTPase,1μM-10μM 体外研究 Mdivi-1是一个可以穿越细胞膜的喹唑酮类化合物,抑制了酵母的Dnm1和人源的Drp1分裂DRPs(发动蛋白相关GTP酶),并且高...
Aims: Dynamin-related protein1 (Drp1) is a large GTPase that mediates mitochondrial fission. We recently reported in Alzheimer's disease (AD) that S-nitrosylation of Drp1 (forming S-nitroso [SNO]-Drp1) results in GTPase hyperactivity and mitochondrial fragmentation, thus impairing bioenergetics and...
Recent studies suggest that amyloid beta (Aβ) and phosphorylated tau interact with the mitochondrial fission protein, dynamin-related protein 1 (Drp1), causing excessive fragmentation of mitochondria and leading to abnormal mitochondrial dynamics and synaptic degeneration in Alzheimer's disease (AD) ...
上海玉博生物科技有限公司 主要致力于“PIERCEPA116987Anti-Dynamin Related Protein 1 Polyclonal Antibody100 µl4275 100 µl”的生产销售。多年的“PIERCEPA116987Anti-Dynamin Related Protein 1 Polyclonal Antibody100 µl4275 100 µl”生产与销售的经验,
Clinton, -1 机译:来自内在无序区域的立体干扰控制线粒体裂变过程中的动力相关蛋白1自组装。 7. Cytoplasmic dynein regulates the subcellular distribution of mitochondria by controlling the recruitment of the fission factor dynamin-related protein-1 [O] . Varadi, Aniko, Johnson-Cadwell, Linda I., ...
related protein-1 (Drp1), thereby decreasing Drp1 accumulation in mitochondria and Drp1-mediated activation of the mitochondrial fission program. We also found that p53 transcriptionally downregulates miR-499 expression. Our data reveal a role for miR-499 in regulating the mitochondrial fission machinery...
Anti-ADL6/DRP2A/ Dynamin-related protein 2A 货号:PAB231227 描述:兔多克隆抗体 纯度:血清 基因:AT1G10290 别名:ADL6, DRP2A, DYNAMIN-LIKE PROTEIN 6, DYNAMIN-RELATED PROTEIN 2A 验证物种:拟南芥,水稻 推荐稀释比:WB 1:1000---1:5000