(2011). Toxoplasma gondii effectors are master regulators of the inflammatory response. Trends Parasitol. 27, 487-495.McClendon, C. L., Kornev, A. P., Gilson, M. K. & Taylor, S. S. Dynamic architecture of a protein kinase. Proc Natl Acad Sci U S A 111, E4623-4631, doi...
Protein kinase CK2 targets a vast array of substrates located in a number of cellular compartments, making the challenge of discriminating among these subs... O Filhol,C Cochet - 《Cellular & Molecular Life Sciences》 被引量: 320发表: 2009年 Dynamic architecture of a protein kinase. N., Mole...
DynamicBind executes “dynamic docking”, a process that performs prediction of the protein–ligand complex structure while accommodating substantial protein conformational changes. DynamicBind accepts apo-like structures (in the present study, AlphaFold-predicted conformations) in PDB format and small-molecu...
et al. Atg8 transfer from Atg7 to Atg3: a distinctive E1–E2 architecture and mechanism in the autophagy pathway. Mol. Cell 44, 451–461 (2011). Article CAS PubMed PubMed Central Google Scholar Hong, S.B. et al. Insights into noncanonical E1 enzyme activation from the structure of ...
Rutuja Patole, in Journal of Systems Architecture, 2024 4.1.1 Constraint Programming (CP) CP is a declarative programming paradigm where constraints are specified on variables, and the problem is solved by finding assignments to the variables that satisfy all constraints simultaneously. In the context...
and gene-regulatory networks to dissect the regulome of homeobox TFs that are strongly associated with SAM maintenance and development in maize. We constructed regulatory networks, offering a valuable resource for dissecting the intricate regulatory mechanisms conferring plant architecture in maize via homeo...
This architecture is conserved in the eukaryotic SMC2-SMC4 heterodimer. Analysis of different deletion mutants of BsSMC unexpectedly reveals that the major DNA-binding activity does not reside in the catalytic ATPase domains located at the ends of a dimer. Instead, point mutations in the hinge ...
Zhao KY, Tung CW, Eizenga GC, Wright MH, Liakat Ali M, Price AH, Norton GJ, Islam MR, Reynolds A, Mezey J, McClung AM, Bustamante CD, McCouch SR (2011) Genome-wide association mapping reveals a rich genetic architecture of complex traits in Oryza sativa. Nat Commun 2:467. https:...
Within the FA complex, a multitude of proteins, binding interactions and complex architecture make resolving mechanosignalling mechanisms at the molecular level a challenge. Here we show that force-induced binding changes occur at the cell surface, resulting in strengthening of a trimolecular complex ...
Fig. 1: Transcriptomic and chromatin architecture dynamics in distinct ATs associated with body weight in changes. a Schematic overview of the experimental design for dietary treatments. b Body weight of pigs (n = 56) during progressive weight gain over 22 weeks, observed every 2 weeks (12...