Denu, Dual-specificity protein tyrosine phosphatase VHR down-regulates c-Jun N-terminal kinase (JNK), Oncogene 21 (16) (2002) 2573-2583.Todd, J. L.; Rigas, J. D.; Rafty, L. A.; Denu, J. M. Dual-specificity protein tyrosine phosphatase VHR down-regulates c-Jun N-terminal kinase ...
Combinatorial control of the specificity of protein tyrosine phosphatases. Curr. Opin. Cell Biol. 13, 182–195 (2001). CAS PubMed Google Scholar Zhang, Y. et al. Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature 430, 793–797 (2004). The first paper...
Dual-specificity protein phosphatases are a subclass of protein tyrosine phosphatases that are uniquely able to hydrolyse the phosphate ester bond on both a tyrosine and a threonine or serine residue on the same protein. Dual-specificity phosphatases have a central role in the complex regulation of ...
The absence of either Ptp2 or Ptp3 does not lead to a significant increase in the amount of basal dually phosphorylated Slt2 (9, 16). Furthermore, the dual-specificity protein phosphatase Sdp1 does not seem to be involved in maintaining a low basal Slt2 phosphorylation (16). Therefore, ...
Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: Implications for substrate specificity The testis- and skeletal-muscle-specific dual-specificity phosphatase (TMDP) is a member of the dual-specificity phosphatase (DSP) subgroup of protein tyro... Seung,Jun,Kim,...
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Here, we further explored protein kinase dual-specificity phosphatases (DUSPs) with the ability to dephosphorylate JNK, and identified DUSP4 as a phosphatase involved in the regulation of corticosteroid sensitivity. The effects of knocking down DUSPs (DUSP1, 4, 8, 16, and 22) by small ...
Mapping the Interaction between the Mitogen-activated Protein Kinase p38α and Its Regulatory Phosphatase♦: Structural Basis for the Regulation of the Mitogen-activated Protein (MAP) Kinase p38α by the Dual Specificity Phosphatase 16 MAP Kinase Binding ...
A novel protein was cloned from a rat liver cDNA library by interaction with the liver glucokinase. This protein contained 339 residues and possessed a canonical consensus sequence for a dual specificity phosphatase. The recombinant protein was able to dephosphorylate phosphotyrosyl and phosphoseryl/...
双重特异性磷酸酶18蛋白(His标签)(Dual specificity phosphatase 18 protein (His tag)),Proteases, Inhibitors, & Enzymes该背景资料请查看产品说明书。 产品描述 Purified recombinant Human Dual specificity phosphatase 18 protein (His tag) 产品形式 保存建议 Store at 4 deg C for short term storage. Aliquot...