The objective of this study was to clarify the suppressive mechanism of PGE2 on the regulation of MMPs and NGF by focusing on mitogen-activated protein kinases (MAPKs) and their endogenous phosphatase, dual specificity phosphatase (DUSP)-1 in human synovial fibroblasts. PGE2 strongly increased D...
Dual specificity phosphatase 1 (DUSP1) dephosphorylates and inactivates MAPK p38. Its expression is induced by pro-inflammatory stimuli, constituting a negative feedback loop to limit the duration of MAPK p38 signaling. Defective negative feedback control causes excessive inflammatory responses in Du...
ARTICLES Intrauterine Growth Restriction Alters T-Lymphocyte Cell Number and Dual Specificity Phosphatase 1 Levels in the Thymus of Newborn and Juvenile Rats YVONNE M. CONTRERAS, XING YU, MERICA A. HALE, CHRIS W. CALLAWAY, DIANA BAREYAN, ROBERT A. MCKNIGHT, LISA A. JOSS-MOORE, ELENA Y. ...
MAPKs are deactivated by dual-specificity phosphatases (DUSPs). We hypothesized that single-nucleotide polymorphisms (SNPs) in DUSP genes could be used to predict PH in BPD. Preterm infants diagnosed with BPD (n=188) were studied. PH was defined by echocardiographic criteria. Genomic DNA ...
DUSP1 (Dual Specificity Phosphatase 1, CL100, HVH1, MKP-1, PTPN10) Basic information More.. Product Name: DUSP1 (Dual Specificity Phosphatase 1, CL100, HVH1, MKP-1, PTPN10) Synonyms: DUSP1 (Dual Specificity Phosphatase 1, CL100, HVH1, MKP-1, PTPN10) CAS: MF: MW: 0 EINECS...
The first green lineage cdc25 dual-specificity phosphatase. Cell Cycle 2004;3(4):513-8.Khadaroo B, Robbens S, Ferraz C, Derelle E, Eychenie S, Cooke R, Peaucellier G, Delseny M, Demaille J, Van De Peer Y, et al (2004) The first green lineage cdc25 dual-specificity phosphatase...
Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock. Journal of Experimental Medicine, 203(1), 15–20. Article PubMed CAS Google Scholar Abraham, S. M., Lawrence, T., Kleiman, A., Warden, P., Medghalchi, M.,...
VHR, DUAL-SPECIFICITY PHOSPHATASE 中文名: 中文别名: CBNumber: CB4471693 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商1 VHR, DUAL-SPECIFICITY PHOSPHATASE化学性质 安全信息 VHR, DUAL-SPECIFICITY PHOSPHATASE性质、用途与生产工艺 ...
Two members of the dual-specificity phosphatase (Dusp) family, dusp6 and dusp2, are believed to be negative regulators of the ERK pathway and are expressed in both embryonic and adult zebrafish, but their specific roles in embryogenesis remain to be fully understood. Using CRISPR/Cas9 genome ...
DUSP1 (dual specificity phosphatase 1), or MKP-1 (mitogen-activated protein kinase phosphatase 1), belongs to a family of around 10 enzymes that inactivate MAPKs3 by catalyzing the removal of phosphate groups from threonine and tyrosine residues in the activation loops of those kinases (1). Th...