Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition. Oncogene 2013;32:564-76.Cagnol S and Rivard N. Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway ...
A Dual Specificity Phosphatase (DUSP) is defined as a type of protein phosphatase that removes phosphorus groups from both phospho-tyrosine and phospho-serine/phospho-threonine residues within a single substrate. These proteins play a role in modulating various neural functions and have been associated...
Dual specificity phosphatase (DUSP) 4 has been described as a negative regulator of MAP kinase signaling, in particular for the ERK1/2 and JNK pathways. We found that DUSP4 expression was upregulated in response to prolonged platelet-derived growth factor (PDGF)-BB stimulation. The PDGF-BB-...
英文别名: DUSP9 (Dual Specificity Phosphatase 9, Map Kinase Phosphatase 4)中文名: 中文别名: CBNumber: CB9994241 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 1 DUSP9 (Dual Specificity Phosphatase 9, Map Kinase Phosphatase 4) 化学性质 ...
Dual specificity phosphatase 4 gene expression in triple negative breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3265. ...
MAPKs are deactivated by dual-specificity phosphatases (DUSPs). We hypothesized that single-nucleotide polymorphisms (SNPs) in DUSP genes could be used to predict PH in BPD. Preterm infants diagnosed with BPD (n=188) were studied. PH was defined by echocardiographic criteria. Genomic DNA ...
VHR, DUAL-SPECIFICITY PHOSPHATASE information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight, uses, prices, suppliers, SDS and more, available at Chemicalbook.
T cell activation is dependent upon phosphorylation of MAPKs, which play a critical role in the regulation of immune responses. Dual-specificity phosphatase 14 (DUSP14; also known as MKP6) is classified as a MAPK phosphatase. The in vivo functions of DUSP14 remain unclear. Thus, we generate...
Dual-specificity phosphatases (DUSPs) are a subclass of protein tyrosine phosphatases (PTPs) that interact with and regulate mitogen-activated protein kinases (MAPKs). DUSPs can positively or negatively control immune responses in cancers, infectious dis
In particular, the dual-specificity phosphatase DSP-4, and polypeptide variants thereof that stimulate dephosphorylation of DSP-4 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-4 activity. The polypeptides and agents may ...