Introduction: Previous studies have demonstrated that Dual-specificity phosphatase 4 (DUSP4) plays an important role in the progression of different tumor types. However, the role and mechanism of DUSP4 in colorectal cancer (CRC) remain unclear. Aims: We investigate the role and mechanisms of DU...
DUSP4 is a member of the dual-specificity protein phosphatase (DUSP) family that regulates mitogen-activated protein kinase (MAPK) activity [1]. MAPK signaling pathways regulate important biological processes including cell proliferation, cell death, and cell survival [2,3,4]. DUSP4 contains a ...
Dual specificity phosphatase-4 (DUSP4) It is a keyenzymein the DUSP family, which are involved in thedephosphorylationand inactivation of MAPKs. Decreased expression or loss of function of DUSP4 has been associated with the progression of certain cancers (Balko et al., 2013; Saigusa...
Mitogen-activated protein kinases (MAPKs) are inactivated by dual-specificity phosphatases (DUSPs), the activities of which are tightly regulated during cell differentiation. Using knockdown screening and single-cell transcriptional analysis, we demonstrate that DUSP4 is the phosphatase that specifically ...
Here, we further explored protein kinase dual-specificity phosphatases (DUSPs) with the ability to dephosphorylate JNK, and identified DUSP4 as a phosphatase involved in the regulation of corticosteroid sensitivity. The effects of knocking down DUSPs (DUSP1, 4, 8, 16, and 22) by small ...
上海玉博生物科技有限公司 主要致力于“VHR Dual-specificity Phosphatase (human) (recombinant) BML-SE333-0050”的生产销售。多年的“VHR Dual-specificity Phosphatase (human) (recombinant) BML-SE333-0050”生产与销售的经验,与各行业新老用户建立了稳定的合作关系
英語化学名:DUSP9 (Dual Specificity Phosphatase 9, Map Kinase Phosphatase 4) 别名: DUSP9 (Dual Specificity Phosphatase 9, Map Kinase Phosphatase 4) CAS番号: 分子式: 分子量:0 EINECS: Mol File:Mol File Browse by Nationality DUSP9 (Dual Specificity Phosphatase 9, Map Kinase Phosphatase 4) Su...
MAPKs are deactivated by dual-specificity phosphatases (DUSPs). We hypothesized that single-nucleotide polymorphisms (SNPs) in DUSP genes could be used to predict PH in BPD. Preterm infants diagnosed with BPD (n=188) were studied. PH was defined by echocardiographic criteria. Genomic DNA ...
dual-specificity protein phosphatase ERK: extracellular-signal regulated kinase JNK: c-Jun amino-terminal kinase MAPK: mitogen-activated protein kinase MEF: mouse embryo fibroblast MKK or MEK: MAPK kinase MKKK or MEKK: MAPK kinase kinase MKP: MAP kinase phosphatase NSCLC: non-small cel...
VHR, DUAL-SPECIFICITY PHOSPHATASE - chemical and physical properties, structure, melting point, boiling point, density, molecular formula, molecular weight, uses, prices, suppliers, and toxicity/safety/hazards/SDS information.