蛋白磷酸酶Cdc25C能够使有丝分裂激酶CDK1/cyclin B去磷酸化,从而促进细胞周期的进程.已经在一些肿瘤细胞中检测到Cdc25C的过量表达,这使得Cdc25C成为肿瘤治疗中的潜在靶标.通过随机筛选,发现了八个Cdc25C的天然新抑制剂(1-8),其IC50值在1.66～75.07μmol/L之间.肿瘤细胞毒试验结果表明,其中四个化合物(化合物3...
CDC25C (Cell Division Cycle 25 Homolog C, Cdc 25C, CDC 25, Dual Specificity Phosphatase Cdc25C, M-phase Inducer Phosphatase 3, MPIP3, PPP1R60) (Biotin)性质、用途与生产工艺 CDC25C (Cell Division Cycle 25 Homolog C, Cdc 25C, CDC 25, Dual Specificity Phosphatase Cdc25C, M-phase Induce...
CDC25s belong to the dual-specificity phosphatase family: they dephosphorylate a threonine and a tyrosine residue of the same protein substrate (T14 and Y15 in CDK1 also known as CDC2). From:Pharmacology & Therapeutics,2007 About this page ...
英文名称: CDC25C (Cell Division Cycle 25 Homolog C, Cdc 25C, CDC 25, Dual Specificity Phosphatase Cdc25C, M-phase Inducer Phosphatase 3, MPIP3, PPP1R60) (Biotin) 英文同义词: CDC25C (Cell Division Cycle 25 Homolog C, Cdc 25C, CDC 25, Dual Specificity Phosphatase Cdc25C, M-phase ...
Dual-specificity protein phosphatases are a subclass of protein tyrosine phosphatases that are uniquely able to hydrolyse the phosphate ester bond on both a tyrosine and a threonine or serine residue on the same protein. Dual-specificity phosphatases have a central role in the complex regulation of ...
Dual-specific Cdc25B phosphatase: in search of the catalytic acid. Cdc25 is a dual-specificity phosphatase that catalyzes the activation of the cyclin-dependent kinases, thus causing initiation and progression of successiv... C Wen,Manuel Wilborn,J Rudolph - 《Biochemistry》 被引量: 129发表: ...
Dual-specificity kinases (DSK; or Ser/Thr/Tyr kinases) phosphorylate their substrates on serine, threonine, and/or tyrosine residues. Dual-specificity kinases intervene in the regulation of cell growth, differentiation, and apoptosis. Dual-specificity kinases include, at least, members of the superfam...
Lehmann GM,Mccabe MJ.Arsenite slows S phase progression via inhibition of cdc25A dual specificity phosphatase gene transcription.Toxicological Sciences. 2007Arsenite Slows S PhaseProgression via Inhibition of cdc25A Dual Specificity Phosphatase GeneTranscription. Geniece M. Lehmann,Michael J. McCabe Jr ...
DSP;Dual specificity protein phosphatase;Mammalian class I dual-specificity cysteine-based phosphatase (DSP);MAPK phosphatase;MKP;Dual-specificity Protein Tyrosine Phosphatase (PTP);DSPase Historical Background In the 1980s, the regulatory role of protein phosphorylation in influencing cell growth, differen...
Furthermore, the dual-specificity protein phosphatase Sdp1 does not seem to be involved in maintaining a low basal Slt2 phosphorylation (16). Therefore, so far, it seems that Msg5 is the most important protein phosphatase involved in maintaining Slt2 with a low activity in the absence of ...