Background Dual-specificity phosphatases (DUSPs) can dephosphorylate both tyrosine and serine/threonine residues of their substrates and regulate T cell-mediated immunity and autoimmunity. The aim of this study was to investigate the potential roles of DUSPs in ankylosing spondylitis (AS). Methods ...
Dual-specificity phosphatases (DUSPs) are a subset of protein tyrosine phosphatases, many of which dephosphorylate threonine and tyrosine residues on mitogen-activated protein kinases (MAPKs), and hence are also referred to as MAPK phosphatases (MKPs). The regulated expression and activity of DUSP...
MAPKs are deactivated by dual-specificity phosphatases (DUSPs). We hypothesized that single-nucleotide polymorphisms (SNPs) in DUSP genes could be used to predict PH in BPD. Preterm infants diagnosed with BPD (n=188) were studied. PH was defined by echocardiographic criteria. Genomic DNA ...
Dual-Specificity Phosphatases 来自 Springer 喜欢 0 阅读量: 45 作者:GP Rédei,GP Rédei,GP Rédei,GP Rédei,GP Rédei 摘要: It recognize more than a single phosphorylated amino acid in a protein and have an important role in signal transduction pathways and differentiation/development, ...
DUSP9 Antibody is a Rabbit Polyclonal antibody against DUSP9. The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They nega...
DUSP6 (alias PYST1), one of the dual-specificity tyrosine phosphatases, is localized on 12q21, one of the regions of frequent allelic loss in pancreatic ca... T Furukawa,T Yatsuoka,EM Youssef,... - 《Cytogenetic & Genome Research》 被引量: 268发表: 1998年 Post-translational regulation ...
The dual-specificity phosphatases (DUSPs) constitute a heterogeneous group of cysteine-based protein tyrosine phosphatases, whose members exert a pivotal role in cell physiology by dephosphorylation of phosphoserine, phosphothreonine, and phosphotyrosine residues from proteins, as well as other non-proteinac...
The MAPK phosphatases (MKPs), also known as dual-specificity phosphatases (DUSPs), are a family of proteins which has been identified as major negative regulators of MAPK activation. The DUSP family consists of 25 members; at least 10 of them have C-terminal catalytic domains and N-terminal...
Thus, the roles of phosphatases are important in cell signaling networks as are those of kinases. The members of the protein tyrosine phosphatase (PTP) family are encoded by approximately 100 genes in humans. They can be divided into two main groups; ‘classical’ PTPs and dual-specificity ...
Protein phosphorylation is regulated by the equal and balanced action of protein kinases and phosphatases in mammalian cells2. Macrophages are innate immune cells activated during microbial infection and are vital mediators of innate immune responses such as phagocytosis, antigen presentation, and secretion...