The LDL receptor-related protein (LRP) family: an old family of proteins with new physiological functions. Ann. Med. 39, 219–228 (2007). CAS PubMed Google Scholar Amin, K., Wasan, K. M., Albrecht, R. M. & Heath, T. D. Cell association of liposomes with high fluid anionic ...
Plasma from patients with renal failure has decreased binding of many drugs. The decreased binding of anionic drugs is pronounced and is apparently due to occupation of protein binding sites by non-dialysable endogenous acidic compounds. Organic bases seem to bind normally, particularly if hypoprotein...
Protein binding in combination with pH, metals and interacting drugs can augment the disposition of raltegravir 来自 ResearchGate 喜欢 0 阅读量: 16 作者:DM Moss,M Siccardi,A Owen 摘要: Introduction. Raltegravir (RAL) is an antiretroviral integrase inhibitor which exhibits high inter- and intra-...
Two high binding drugs, diazepam and nortriptyline, were examined to verify the advantages offered by the new proposed method and their Ka values were computed using the experimental results and the mathematical equation developed. The resulting data agreed well with theoretical predictions....
G protein-coupled receptors (GPCRs) are transmembrane proteins that participate in many physiological processes and represent major pharmacological targets. Recent advances in structural biology of GPCRs have enabled the development of drugs based on the receptor structure (structure-based drug design, SB...
For predictions of protein–ligand affinities, the tertiary structure of the protein, the active conformation of the ligand and the binding mode must be known. Force field The functional form and parameter sets used to describe the potential energy of a system of particles. Free energy The ...
Plasma Protein BindingApproximately 99%.EliminationMetabolismDolutegravir primarily metabolized by UGT1A1; CYP3A plays only minor role. Data from healthy individuals indicate that UGT1A1 genotypes conferring poor dolutegravir metabolism result in 32% lower clearance and 46% higher AUC of the drug compared...
As mentioned previously, drugs with extravascular distribution such as those with high peripheral tissue binding contribute to a large apparent volume of distribution, while drugs that are polar with low lipid solubility or which highly bound to plasma protein account for small apparent VD. In multipl...
The combined use of gene coexpression data and protein interaction data improves the confidence of the corresponding PPI network, thereby enabling a high-confidence ASD-related molecular network to be obtained. The strong correlation between network topology and biological function is associated with the...
Has been used orally (in combination with other antiemetic agents) for prevention of acute and delayed nausea and vomiting associated with highly emetogenic cancer chemotherapy† [off-label], including high-dose cisplatin therapy.For prevention of nausea and vomiting associated with highly emetogenic...