such as growth, development, and reproduction. Moreover, nucleic acids can be used to modify genetic information to treat various diseases.1,2With the advancement of the life sciences, proteomics, and genomics methods, nucleic acid drugs (NADs) have been...
Darzalex Faspro is used to treat specific multiple myeloma patients and is also FDA-approved to treat adults with newly diagnosed light chain (AL) amyloidosis. Darzalex Faspro advantages over Darzalex are that it is faster to administer, it has less systemic administration-related reactions (ARRs)...
New Drugs Treat Rare Heart Disease Caused by Transthyretin-Mediated Amyloidosisdoi:info:doi/10.1097/01.NAJ.0000580244.26161.f0Aschenbrenner, Diane S.AJN
Colchicine is used to treat the following conditions: Amyloidosis(off-label) Aphthous Stomatitis, Recurrent(off-label) Behcet's Disease(off-label) Cardiovascular Risk Reduction Constipation, Chronic(off-label) Familial Mediterranean Fever Fibromatosis(off-label) ...
hereditary transthyretin-mediated amyloidosis by degrading mRNA encoding transthyretin (TTR).97Thus far, six siRNA drugs have received international approval. With the ongoing development of novel chemical modifications and targeted delivery systems, more siRNA drugs are anticipated to enter the market soon...
,5vasopressin mRNA injected into the hypothalamus of Brattleboro rats was found to successfully express vasopressin,357mRNA vaccine encoding tumor antigen in mice,171first clinical trial of mRNA-engineered DCs vaccine strategy,6,7,8first DC vaccine with autologous tumor mRNA was used to treat ...
As nitrogen mustard therapy can contribute to the extensive and rapid development of amyloidosis, it should be used only if foci of acute or chronic suppurative inflammation are absent. Alkylating agents are carcinogenic, mutagenic and tera- togenic. Oligomenorrhea or azoospermia can be induced by ...
Information on Alnylam’s RNAi drug Onpattro, used to treat nerve damage from hereditary transthyretin-mediated amyloidosis Details pertaining to market share and company profiles of leading players of the industry Report Scope The “Market at a Glance Pharmaceuticals” provides a sampling of the mark...
Inotersen (brand name Tegsedi) is a self-administered, once-weekly injection that may be used to treat polyneuropathy caused by hereditary transthyretin-mediated amyloidosis (hATTR) in adults.Inotersen is an antisense oligonucleotide, a short piece of synthetic RNA that works by attaching to and...
Eplontersen (Wainua) is used to treat polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR-PN or ATTRv-PN), which is a rare, progressive disease that can be fatal if not treated.