Leqembi (lecanemab-irmb) is an anti-Aβ protofibril antibody and has been shown to reduce brain amyloid and modestly slow cognitive decline in adult patients with early Alzheimer disease. It is thought to slow down the progression of Alzheimer by neutralizing and eliminating the toxic amyloid-...
fecal matter transplant from healthy donors into AD patients, microbiome modifying drugs, and direct targeting of gut microbiome controlled neuroinflammatory pathways may potentially be disease modifying therapeutic strategies and may reduce amyloid, tau, and neurodegeneration...
MEDICAL ethicsMEDICAL logicAlzheimer's disease (AD) is an incurable, progressive deterioration that ends, eventually, in death. For many years, AD's hallmark etiological feature was beta-amyloid plaque accumulation in the brain, but, to date, costly drugs designed to redu...
fecal matter transplant from healthy donors into AD patients, microbiome modifying drugs, and direct targeting of gut microbiome controlled neuroinflammatory pathways may potentially be disease modifying therapeutic strategies and may reduce amyloid, tau, and neurodegeneration...
This drug, when delivered to patients in the very early stages of Alzheimer's (which makes early recognition even more important) not only eradicates amyloid from the brain, but also seems to have a modest effect on the clinical course of illness over a period of 18 months. ...
Serum and cerebrospinal fluid proteins or imaging techniques may be useful in future as biomarkers to identify the relative contribution of Lewy-related and Alzheimer-type pathology in a given case of PDD and to inform the rational use of drugs that can reduce aggregation and beta-amyloid ...
Pepys MB. The pentraxins 1975–2018: Serendipity, diagnostics and drugs. Front Immunol. 2018;9:1–18. https://doi.org/10.3389/fimmu.2018.02382. Article CAS Google Scholar Pilling D, Gomer RH. The development of serum amyloid p as a possible therapeutic. Front Immunol. 2018;9:1–10. htt...
For behavioral variant frontotemporal dementia, for example, antidepressant andantipsychotic medicationsmay help reduce behavior problems, but all drugs have side effects, so they must be considered with caution. Medications used for Alzheimer's disease may not be effective, which is another reason an ...
Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wodd K: Peripherally administered antibodies against amyloid beta peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 2001, 6: 916-919....
kidneys. Once enough amyloid protein accumulates in surrounding tissues, the disorder causes enlargement and swelling. Several treatment options including stem cell therapy and, on occasion, certain cancer drugs are available to prevent serious complications in people who suffer from these and related ...