In recent years, the development of new drugs has brought new hope to patients. This review presents the latest advances in drug development and clinical application to provide a reference for clinicians managing transthyretin cardiac amyloidosis....
Drugs for Heart Disease With Rare Cause The FDA recently approved 2 drugs for adults with cardiomyopathy caused by transthyretin-mediated amyloidosis (ATTR), a rare and life-threatening disease. The oral medications, tafamidis meglumine and tafamidis, are the first to receive ... F Sancar - 《Ja...
monocyte–cardiomyocyte interactions, and improved myocarditis and cardiac ischemic/reperfusion (I/R) injury in vivo [92]. This DARPin may be a novel tool that inhibits inflammation by preventing interaction between leukocyte ß2-integrins and adhesion molecules, as well as other downstream therapies....
Amyloidosis is a disease of protein misfolding that ultimately impairs organ function. Previously, we demonstrated that amyloidogenic light chains (κ1, λ6, and λ3 subtypes), internalized by cardiac fibroblasts, enhanced sulfation of secreted glycosaminoglycans. In this study, we investigated the ...
In the last decade, messenger ribonucleic acid (mRNA)-based drugs have gained great interest in both immunotherapy and non-immunogenic applications. This surge in interest can be largely attributed to the demonstration of distinct advantages offered by v
In June 2022, Alnylam® Pharmaceuticals announced that another siRNA that reduces TTR protein production, AMVUTTRA™ (vutrisiran), received the FDA approval, followed by the EMA approval in September 2022, for the treatment of hATTR amyloidosis with polyneuropathy69. AMVUTTRA™ is a siRNA ...
among others. Schedule III drugs along with the other types of scheduled drugs can be found under the category of controlled substances and are placed under these schedules based on their potential for abuse, whether they are likely to cause dependence as a result of abuse or whet...
Profile Congo red is used as a stain in the diagnosis of amyloidosis. It causes amyloid in tissue samples to fluoresce under polarised light. Conivaptan Hydrochloride (rINNM) ⊗ CI-1025; Conivaptan, Chlorhydrate de; Conivaptán, hidrocloru- ro de; Conivaptani Hydrochloridum; YM-087 (...
amyloidosis。cardiacvalvulardegenerativechangesandannularcalcification,fibrousinfiltrationoftheconductionsystem,andlossofnatural pacemakercellsandthesechangescouldhaveaprofoundefectonthedevelopmentofarrhythmias.1rtleage-relatedcardiac electrophysiologicalchangesincludeup.anddown—regulationofspecificionchanne1expressionandintmcell...
Highly irrigated organs (liver, kidney, spleen) are easier to target than cardiac muscle, lung, and skin which are weakly irrigated. Currently, new therapeutic approaches are under investigation to increase bioavailability and biodistribution. For example, coupling ASOs to a fatty acid chain [72] ...