Orthotopic liver transplantation and combined hepato-heart transplantation have been clinically effective means of treating transthyretin cardiac amyloidosis mutants for many years. However, transplantation has many limitations in clinical practice. In recent years, the development of new drugs has brought ...
The clarification of mechanisms of cardiac damage is offering new potential therapeutic targets, and several treatment options with a relevant impact on prognosis are now available. 展开 关键词: Cardiac amyloidosis Heart failure NT-proBNP Cardiac imaging Diastolic function Systolic function Cardiac toxicity...
Like polyneuropathy, cardiac amyloidosis is a prominent clinical feature of hereditary amyloidosis, namely of the autosomal dominant transthyretin (TTR) type. All 28 cases of TTR amyloidoses reported so far were heterozygotes for a single nucleotide change in the gene for TTR that resulted in amino...
Cardiac amyloidosis associated with the transthyretin Ile122 mutation in a Caucasian family The Ile 122 transthyretin variant associated with restrictive cardiomyopathy has been described in African-Americans and estimated to be present in approxi... KH Asl,M Nakamura,T Yamashita,... - 《Amyloid-jour...
Tissue Doppler and strain imaging: a new tool for early detection of cardiac amyloidosis. Amyloid. 2009;16(2):63-70.Porciani MC, Lilli A, Perfetto F et al (2009) Tissue Doppler and strain imaging: a new tool for early detection of cardiac amy- loidosis. Amyloid 16:63-70...
The Aβ hypothesis is the mainstream hypothesis for the pathogenesis of AD and has influenced the direction of drug development over the past three decades. According to the hypothesis, the pathological progression of AD originates from asymptomatic cerebral amyloidosis many years before the onset of...
In a pooled safety population of 898 patients with multiple myeloma (N=705) or light chain (AL) amyloidosis (N=193) who received DARZALEX FASPRO® as monotherapy or in combination, 9% of patients experienced a systemic a...
advanced renal impairment can accelerate renal injury progression and may contribute to the high rate of clinical complications in both CKD patients in conservative and dialysis treatment. Major complications include cardiovascular disease, atherosclerosis, amyloidosis and DNA-Damage-Associated Malignancy [36]...
Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. Neurobiol Aging , 2017 , 49: 60 -68 CrossRef PubMed Google Scholar [46] Mancuso C, Santangelo R. Alzheimer’s disease and gut microbiota modifications:...
hormone replacement therapy, drug therapy, treatment with blood thinners including coumadin, warfarin, and antiplatelet drugs, treatment with excitatory amino acid antagonists, brain edema, arterial amyloidosis, aneurysm, ruptured aneurysm, arteriovenous malformations, or any other conditions which may affect...