How to select the optimal drug to treat different types of osteoporosis has become the focus of clinical treatment. Besides, with the deepening of research and understanding on bone metabolism, the upgrading of existing drugs, the compatible use of drugs with different action mechanisms, new ...
et al. A classification of drug substances according to their mechanism of action. Pharmazie 59, 579–589 (2004). CAS PubMed Google Scholar Swinney, D. C. Biochemical mechanisms of drug action: what does it take for success? Nature Rev. Drug Discov. 3, 801–808 (2004). Article CAS ...
Possible anti-inflammatory role of COX-2 In 1971, Sir John Vane demonstrated for the first time that the mechanism of action of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs)... M Kapoor,O Shaw,I Appleton - 《Current Opinion in Investigational Drugs》 被引量: 52发表: 200...
The primary focal point of this lesson will be on the subject of the chemistry of medical drugs. Our main topics of discussion will include how they are classified and their mechanism of action. Can't Live Without Them When you hear the term medical drug what's the first thing that comes...
we summarize key preclinical and clinical data relating to the proposed mechanism of action of the recently approved DMT teriflunomide in MS. Teriflunomide selectively and reversibly inhibits dihydro-orotate dehydrogenase, a key mitochondrial enzyme in the de novo pyrimidine synthesis pathway, leading to ...
Selected factors that influence remyelination and their mechanism of action. Several factors/signalling pathways, which positively (green) or negatively (red) influence remyelination by altering known necessary steps during the remyelination process have already been identified.BMPbone morphogenic proteins,...
The mechanism of action of a new class of cardiotonic drugs from natural sourcesdoi:10.1016/s0021-5198(19)48646-0Y. OhizumiJapanese Journal of Pharmacology
In this review, we briefly describe recent developments in determining the crystal structure of 3CLpro and highlight its structural differences among SARS-CoV-2, MERS-CoV and SARS-CoV. We further summarise new insights into 3CLpro inhibitors and their mechanisms of action, with a particular focu...
Baba, W.I.; Tudhope, G.R. and Wilson, G.M.: Site and mechanism of action of the diuretic, triamterene. Clinical Science 27: 181–193 (1964). PubMedCASGoogle Scholar Baek, S.M.; Brown, R.S.; Kark, A.E. and Shoemaker, W.C.: Early prediction of acute renal failure and recov...
Recent advances in neuroscience and molecular neurochemistry have substantially increased the knowledge of the neuropathobiology of senile dementia and Alz