One of these, T-705 (favipiravir), has a mechanism of action that is not fully understood but is suggested to target influenza virus RNA-dependent RNA polymerase. We investigated the mechanism of T-705 activity against influenza A (H1N1) viruses by applying selective drug pressure over multiple...
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Hengrui Medicine, a China-based specialty pharmaceutical company with annual net sales of over U.S. $1.6 billion, is committed to the development, manufacturing and commercialization of human therapeutics especially the innovative drugs to address the unmet medical needs in Greater China and Global ...
Mechanism of Action Fms-like tyrosine kinase 3 inhibitors; Platelet-derived growth factor beta receptor antagonists; Proto-oncogene protein c-kit inhibitors; Type 3 fibroblast growth factor receptor antagonists; Vascular endothelial growth factor receptor antagonists Orphan Drug Status Orphan designation ...
Mechanism of Action The mechanism of action of metaxalone in humans has not been established, but may be due to general central nervous system depression. Metaxalone has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fiber. Pharmacokinetics The ...
12.1 Mechanism of Action Allopurinol is a structural analogue of the natural purine base, hypoxanthine. Allopurinol acts on purine catabolism, without disrupting the biosynthesis of purines. It reduces the production of uric acid by inhibiting the biochemical reactions immediately preceding its formation....
Metabolism, mechanism of action, and clinical applications. Chem Biol. 2014;21(3):319–29. Article PubMed PubMed Central CAS Google Scholar Pludowski P, et al. Vitamin D supplementation guidelines. J Steroid Biochem Mol Biol. 2018;175:125–35. Article PubMed CAS Google Scholar Al Mheid...
12.1 Mechanism of Action Glipizide primarily lowers blood glucose by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. Sulfonylureas bind to the sulfonylurea receptor in the pancreatic beta-cell plasma membrane, leading to clo...
In support of this view, ligated RAR-α was recently found to co-immunoprecipitate with ligated GR and to physically interact directly in thymocytes.63 A similar mechanism of direct protein- protein interaction and tethering of GR and AP-1 (c-Jun/c-Fos) has been suggested to contribute to ...
Febuxostat is contraindicated with concomitant use oftheophyllineandchemotherapeutic agents, namelyazathioprineand6-mercaptopurine, because it could increase blood plasma concentrations of these drugs, and therefore their toxicity.[3][5] Mechanism of action ...