DGIdb数据库(Drug-Gene Interaction database),是一个药物-基因相互作用数据库,提供了基因与其已知或潜在药物关联信息,目前已经更新到4.0版本。里面的基因主要是癌基因,但是也有一些其他疾病(例如阿尔兹海默病、心脏病、糖尿病等)的相关基因。DGIdb一共有超过14000种药物-基因的相互作用,涉及2600个基因和6300中靶向这些...
Leveraging the drug-gene interaction database we identified 47 drugs, including dexamethasone and spironolactone, among others. Considering genetic variants within 卤 10 kb of ACE2-network genes we identified miRNAs whose binding sites may be altered as a consequence of genetic v...
The annotations of drug-gene interaction terms are publicly available in Drug Gene Interaction (DGIdb v5.0) database at https://www.dgidb.org/. The information on FDA-approved drugs for common psychiatric disorders was extracted from DrugBank 5.1.1, which can be freely downloaded from https://...
Data The Drug-Gene Interaction Database 4.0(DGIdb4.0)is a user-friendly search tool and comprehensive database that provides information on gene-drug associations between known or potential drugs. Currently, DGIdb 4.0 has 10,606 druggable genes and 54,591 drug-gene interactions, covering 41,102 ...
-STRING: Database of protein-protein interaction networks -CORUM: The comprehensive resource of mammalian protein complexes -Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathways: Pathways derived from the KEGG database based on molecular interaction, reaction and relation networks DrugThatGene Table ...
This analysis estimates the statistical significance of overrepresented compounds from multiple drug-gene interaction databases to construct a Pharmacome. We selected compounds with adjusted p-value <0.05. Compounds with no clinical indications (e.g., paraquat and ethanol) were filtered out from the ...
The Protein sequence was retrieved from NCBI databaseand using Swiss Homology method the protein structure was constructed. Linux based software TRITON was used tostudy and determine the mutations in the structure. For predicting the variations of drug binding capacities of thechemotherapeutic agents, ...
repositioning. By accumulating testing data, cutoff values forRgenein various cases can be determined to investigate the drug repositionability. Furthermore, since various drug combinations were tested in some clinical trials,Rgenewill be applicable for the studies of pharmacodynamic drug interaction. ...
(CTD)13or Drug-Gene Interaction Database (DGIdb)27provide valuable resources regarding DGIs and their association types (e.g. acetylation, methylation, phosphorylation), to our knowledge these resources have not been used to predict potential DDIs and associated ADR types in common practice. We ...
We chose DrugBank [33] because it is a comprehensive, versioned, and scientifically curated (i.e., robust) database with consistent support for in silico drug design and repositioning space exploration [32]. 2.2. Building the Drug–Drug Similarity Network The bipartite drug–gene interaction netwo...