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R. The influence of excipients on drug release from hydroxypropyl methylcellulose matrices. J. Pharm. Sci. 93, 2746–2754 (2004). Article CAS Google Scholar Jeong, B., Bae, Y. H. & Kim, S. W. Drug release from biodegradable injectable thermosensitive hydrogel of PEG–PLGA–PEG triblock...
Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery and have found clinical use. Hydrogels can provide spatial and temporal control over the release of various therapeutic agents, including small-molecule drugs, macromolecular drugs and cells. Owing to their tunable ...
thoroughly filling the wound area and protecting the wound site from the external environment. The hydrogel is made from naturally occurring polymers, CMC and DACNC. And finally it dissolves as needed and take advantages of amino acid solution to accelerate the healing of deep burn wound and prev...
Kinetics of drug release from hydrogel matrices The release of water soluble drugs from initially dehydrated hydrogel matrices generally involves the simultaneous absorption of water and desorption of drug via a swelling-controlled diffusion mechanism. Thus, as water penetrates a glas... IL Ping - 《...
First−order release,ln1−MtM∞=−kt Hixson-Crowell model (drug release from systems with limitations in dissolution rate) 1−MtM∞3=−kt Baker-Lonsdale model (drug release from spherical shape matrices with diffusion rate limitation) ...
The present MCPS allow controlled doses of macromolecular or microparticulate drugs being uniformly loaded into controlled-release matrices based on a physically crosslinked, biodegradable hydrogel.doi:10.2174/1874126600701010068Chiara ZainoYlenia Zambito
The swelling and hydration of a hydrophilic pectin-HPMC mixture, to form a hydrogel layer provided a more predictable release than that of compression pressure, in an aqueous medium. 6.2.4 Amounts of outer shell The amount of material in the outer coating shell is a key parameter in ...
In vitro release behavior of BSA, which was used as the model protein or peptide drug, from BSA loaded composite hydrogel was studied in detail. The procedure was similar to section 2.7.2, except that the initial drug loading amount were 4 mg and 8 mg, respectively. The amount of BSA pr...