英文检索词为“DNA hydrogel,drug delivery,bone defect,osteogenic differentiation,osteogenic factor”,中文检索词包括“DNA水凝胶、药物输送、基因治疗、应用、细胞培养、骨缺损、成骨分化、成骨因子”,检索时间为2021年1月至4月,主要检索...
Due to its high water solubility, H-bondings, and pi-pi stacking interactions, DNA offers enormous opportunities to fabricate new supramolecular architectures through self-assembly. DNA-based hydrogels are highly biocompatible cargos that could be engineered into novel delivery vehicles for small ...
此外,数据显示在2010年左右,纳米技术(nanoparticles)、微球技术(microspheres)引起了广泛的学术兴趣,在随后的几年,围绕这两项技术涌现出许多细分和延伸的研究,生物可降解聚合物(biodegradable polymers)、聚合物药物递送系统(polymeric drug delivery systems)研究数量迅速增加并得到持续关注,从市场信息来看,这些突破在后续先...
在随后的几年,围绕这两项技术涌现出许多细分和延伸的研究,生物可降解聚合物(biodegradable polymers)、聚合物药物递送系统(polymeric drug delivery systems)研究数量迅速增加并得到持续关注,从市场信息来看,这些突破在后续先后被应用到产业领域中;2020年至今,3D打印(3d printing)、exosomes、机器学习(machine learning...
DNA hydrogel is one of DNA-based nanomaterials with unique advantages such as precise self-assembly, programmability, addressability, high stability, excellent biocompatibility and biodegradability, and tunable versatility. These features have greatly promoted the development of DNA hydrogels in various applic...
In summary, CDs mediated DNA hydrogel was used as drug delivery vehicle for sustained release of drug. The amine functionalized surface of CDs was conjugated to C-rich ssDNA and processed for network formation through the formation of DNA i-motif structure. The intense fluorescence of the CDs wa...
Another strategy is to use the enzymatic action of the DNA hydrogel to disintegrate the hydrogel structure, resulting in a slow release of the encapsulated drug. Zhang et al. [95] used an enzyme-responsive DNA hydrogel (DSH) as a metformin (MET) delivery vehicle for the treatment of ...
Then, new concepts, properties, and applications are highlighted such as DNA鈥恇ased biosensor devices, drug delivery platforms, and cell scaffolds. With the 2018 Nobel Prize in Physiology or Medicine being awarded to cancer immunotherapy underscoring the importance of this therapy, DNA hydrogel ...
The retention of bioactivity of the drug molecule was confirmed by testing its effect on osteogenic stem cell differentiation and stem cell migration. We envision that the formulated hydrogel could be effectively used in future as an injectable drug delivery platform for localized delivery of small ...
5c, d). These findings suggest that DNA hydrogel constructs are ideal vectors for the delivery of DNA-damaging agents such as Dox in cancer cells. Testing of QDHs in xenograft model We sought to test whether ZnS-QDH could be used as drug carriers in an animal model. The toxicity in mice...