Zero order release of a drug from monolithic polymer devices fails because the drug concentration gradient within the matrix falls with time. In principle, it should be possible to maintain this concentration gradient constant via the introduction of a ratelimiting barrier to solute diffusion at the...
Controlled drug release from gels using surfactant aggregates: I. Effect of lipophilic interactions for a series of uncharged substances J. Pharm. Sci., 90 (2001), pp. 1216-1225 View in ScopusGoogle Scholar [5] R. Mulik, V. Kulkarni, R.S. Murthy Chitosan-based thermosensitive hydrogel con...
Therefore, our multilayered hydrogel could be loaded with PTX at different locations to control the release profile and act as a drug reservoir. The amount of PTX incorporated in the hydrogel samples increased with the number of layers but was not directly proportional to the number of layers. ...
Drug release from cylindrical monolithic hydrogel devices containing progesterone were evaluated. It was found that the rate of water influx strongly influences the initial release rates. It was postulated that the initial release rates. It was postulated that the initial release rates should decrease ...
Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery and have found clinical use. Hydrogels can provide spatial and temporal control over the release of various therapeutic agents, including small-molecule drugs, macromolecular drugs and cells. Owing to their tunable ...
The desired kinetics, duration, and rate of solute release from hydrogels are limited to specific conditions, such as hydrogel properties, amount of incorporated drug, drug solubility, and drug-polymer interactions. This review summarizes the compositional and structural effects of polymers on swelling,...
Nanofiber hydrogel rheology becomes even more critical for 3D or 4D printable systems that should maintain sustained drug delivery rates. 展开 关键词: nanofiber hydrogel nanofiber hydrogel drug release gel rheology nanofiber hydrogel nanofiber hydrogel drug release gel rheology ...
In response, a range of strategies have been explored to reduce the release rate of drug from hydrogels. These strategies can be categorized by whether they enhance the interactions between the drug and the hydrogel matrix and/or increase the diffusive barrier to drug release from the hydrogel. ...
Drug release is a phenomenon controlled by diffusion or dissolution or both. Generally, diffusion-controlled drug release is predicted byHiguchi (1963)square root of time model. This model is particularly effective when diffusion-controlled release occurs from porous matrix; in this case, bathing flui...
By the use of caffeine as a model drug, we investigated the caffeine-controlled release from hydrogel systematically as a function of pH value, temperature, and crosslinker content. The caffeine release was sensitive to the temperature. Only 55% caffeine was released from the hydrogel at room ...