药物相互作用DRUG-DRUG INTERACTION.ppt,个体预测法 给药次序 先使用相互作用药(precipitating drug)待病情稳定后,给予目标药(index drug) ,除非停用相互作用药,否则不会出现相互作用 例如西咪替丁和香豆素类的相互作用 个体预 测 疗程 相互作用的发生时间长短不一致
药物在体外和药物在体内的相互作用药物在体外的相互作用属药剂学(Pharmaceutics)或药物化学(Medicinalchemistry)的研究范畴药物在体内的相互作用属临床药理学(Clinicalpharmacology)和临床药学(Clinicalpharmacy)的研究范畴 3药物相互作用的结果 药效增强或减弱毒副作用增加或减轻药物理化性质变化出现始料...
药物在体外和药物在体内的相互作用药物在体外的相互作用属药剂学(Pharmaceutics)或药物化学(Medicinalchemistry)的研究范畴药物在体内的相互作用属临床药理学(Clinicalpharmacology)和临床药学(Clinicalpharmacy)的研究范畴 3药物相互作用的结果 药效增强或减弱毒副作用增加或减轻药物理化性质变化出现始料...
druginteraction-wy DrugInteractions YunWANG，PhDAssociateProfessorDepartmentofClinicalPharmacology Example Terfenadine+ketoconazole:•KetoconazoleisanenzymeinhibitorIncreasetheserumconcentrationofterfenadine •Excessiveterfenadine Lethalarrhythmias In1998,terfenadinewasremovedfrommarket.2 Outline •Introduction -Definition ...
2. Biological characterization Pharmacology Drug metabolism Toxicology Prospective drug substances must undergo preclinical testing for biologic activity to assess their potential as useful therapeutic agents. pharmacology Drug metabolism toxicology 1) Pharmacology embraces the physical and chemical properties, bioc...
1 Drug-Drug Interaction Concept Paper: Issues Related to CYP/Transporter- and Induction-Based Interactions and Multiple- Inhibitor Drug Interaction Studies: Relevant Principles of Drug Interaction Concept Paper Shiew-Mei Huang, Ph.D. Deputy Director for Science Office of Clinical Pharmacology & Biopharm...
Dose-response curves are ubiquitous in pharmacology and biology, yet potency and effect size are often estimated even when there is no response. Here, authors present a statistical framework to assess curve significance and demonstrate how this aids drug mode of action analysis in large public datas...
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Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA Chen Chen, You Wu, Naxhije Berisha, Mandana T. Manzari, Kristen Vogt & Daniel A. Heller Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY, 10065, USA Chen Chen, You ...