CARBOXYLIC ACID AMIDE-CONTAINING DRUGUse of compounds of the formula ##STR1## wherein R.sup.1, R. sup.2, R. sup.3, R.sup.4 and R.sup.5, independently are hydrogen, alkyl, or C.sub.3- 7 -cycloalkyl or two adjacent residues R.sup.1 to R.sup.5 taken together with adjacent ...
The presence of carboxylic acid in the system makes it more suitable for designing a pH-responsive delivery system. It almost bears all the qualities of a good pharmaceutical polymer such as biodegradable nature, nontoxic behavior, biocompatibility, etc. But at the same time, it is also ...
Additionally, the PLS/FT-IR process showed that differences of control cells and those exposed to AuNPs-drug conjugate were related to their diverse lipid, DNA/RNA, and amide II and I values. AuNPs-drug conjugate affected nucleic acids of all cell categories. Thus, MCF-7 cells indicated a ...
The research notebook containing the code for implementing the machine learning algorithms and figure generation has been deposited in DRUM, https://doi.org/10.13016/0jck-hnnv114. All machine learning models can be reproduced by following the code in the research notebook in the compressed folde...
2M). After the crosslinking of HA with GOQD by carbodiimide reaction, the peak for C = O at 1725 cm−1 almost disappeared and the intensity of the peak for the amide-I bond at 1627 cm−1 increased thus signifying successful conjugation. Also, another characteristic peak at 1385 ...
and find potential new drug targets. The 442 complete genome dataset was used to estimate the pangenome ofM. tuberculosis. This study involved phylogenomic classification and in-depth analyses. Sequential filters were applied to the conserved core genome containing 2754 proteins. These filters assessed...
et al. Use of enzyme inhibitors to evaluate the conversion pathways of ester and amide prodrugs: a case study example with the prodrug ceftobiprole medocaril. J. Pharm. Sci. 101, 1242–1252 (2012). This study describes experiments involving the in vitro evaluation of enzymes responsible for ...
Plasma hydrolysis rates were inversely dependent on the lipophilicity of the ester.Derivatives containing the ethyl hippurate carrier are useful prodrugs for carboxylic acid-containing drugs with pKa > 3.5, such as non-steroidal anti-inflammatory agents and valproic acid. 展开 ...
Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4-dimethyl- 1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase. J. Med. Chem. 46, 1116–...
The invention provides a salt, particularly an ionic liquid, of a non-steroidal anti-inflammatory drug (NSAID) comprising a carboxylic acid and an organic amine compound, as well as a method of producing such a salt. Inventors: Hanma, Noritaka (Higashikagawa-shi, JP) ...