Decarboxylative cyclization of 1-methylindole-2-or indole-3-carboxylic acids with substituted propargyl alcohols underLewis (for 1-methylindole-2-carboxylic acid) or Br酶nsted (for1-methylindole-3-carboxylic acid) acid catalysis gives the same 3,4-dihydrocyclopentaindoles,demonstrating 3- to 2-...
1Chapter 16 Amines and AmidesAmines2AminesAmines Are derivatives of ammonia NH3. Contain N attached to one or more alkyl or arom..
OF THE DISCLOSUREDescribed herein are craboxylic acid amide compounds or carboximide compounds represented by the general formula:wherein Z represents a group of the formula:(1 ) ora group of the formula:(2)wherein A constitutes along with two carbon atoms respectively represented by .alpha. a...
Domino Transformation of 1,3-Dicarbonyl Compounds: One-Pot Regio-, Chemo- and Stereoselective Access to Valuable ,-Difunctionalized -Ketoesters and Amides... Hadjira,Habib-Zahmani,Salih,... - 《Cheminform》 被引量: 3发表: 2003年 Trimethylsilyl azide-promoted acid-amine coupling: A facile one...
(3ao), the amide bond formation between carboxylic acid and nitro groups is still predictable. These are cases which are challenging for classical amidation strategies with coupling reagents or transition metal-catalyzed aminocarbonylation53,54,55. There is also good functional group tolerance for ...
it can combine with alcohol compounds to generate corresponding ester compounds, which have wide applications in fields such as spices. The acylation reaction can combine DusQ 21 carboxylic acid with amine compounds to form amide compounds, which play an important role in the synthesis of bioactive...
acid. Base-catalyzed decarboxylation can also be achieved and, generally, milder conditions are required for the 2-carboxylic acids than for the 3-isomers. The reaction is also promoted by electron-donating substituents and retarded by electron-withdrawing groups. Thus, for example, steam ...
The structures of the compounds were studied using 1H NMR spectrometry. A reaction mechanism has been put forward to explain the experimental data. 展开 关键词: Esterification 2-Hydroxy alkylamide Carboxylic acid Oxazolinium DOI: 10.1016/0033-0655(93)80038-C 被引量: 26 ...
The coupling of an amine with a carboxylic acid to form an amide bond is the most popular chemical reaction used for drug discovery1. However, there are many other ways to connect these two common functional groups together. Here we show computationally that amines and acids can couple via ...
The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof...