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It is known that the function and turnover of the mitochondrial fission protein, DRP1 is regulated by post-translational modifications, like phosphorylation, SUMOylation, ubiquitylation and S-nitrosylation [2, 10]. While phosphorylation of DRP1 alters its activity, ubiquitylation promotes degradation. ...
Abstract P3137: Drp1-dependent Mitochondrial Fission Induces Vascular Smooth Muscle Cell Dysfunction Through Kruppel-like Factor 4 Upregulationdoi:10.1161/res.131.suppl_1.P3137Angiotensin IIVascular diseaseMitochondriaIntroduction: Vascular smooth muscle cell (VSMC) phenotypic switching and subsequent VSMC ...
Dynasore (Dynamin Inhibitor I) 是一种可渗透细胞的化学物质,可逆且非竞争性地抑制 dynamin 1/2 的 GTPase 活性。
Drp1 is a mechanochemical protein encoded by theDNM1Lgene and is a member of the dynamin-like GTPase superfamily. Although the functional domains of Drp1 have been briefly characterized [17], their functional significance has not been thoroughly explored. Moreover, there have been no comprehensive...
We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
These results indicate that inhibition of Drp-1-mediated mitochondrial fission induces replicative senescence-like phenomena in younger BMSCs, while Drp1 activation partially improves the functions of BMSCs. Thus, Drp1-mediated mitochondrial dynamics are upstream regulators of the senescent state and ...
3.4. Effect of FBXL4 overexpression on HFpEF-induced changes in mitochondrial morphology, dynamics, function as well as intracellular Ca2+ transport and autophagy Given that HFpEF is associated with mitochondrial fragmentation manifested as smaller and fatter mitochondria [47], we went on to evaluate ...
Function:Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mi...
目的: LED光源广泛使用正引发蓝光视觉危害问题.ROS是视网膜蓝光损伤的关键因子,但ROS的主要来源线粒体和NADPH氧化酶如何协调参与视网膜蓝光损伤机制尚不明.本研究的目的是探讨蓝光照射时Drp1介导的线粒体分裂在调控视网膜神经节细胞ROS产生和NADPH氧化酶表达的作用机制;从而更全面认识线粒体-NADPH氧化酶协同参与视网膜蓝光...