In vitro and mouse studies suggest that decreasing DRP1 activity could help treat HD. In human neurons expressing a mutant form of the huntingtin (HTT) protein, expression of a DRP1 variant with less enzymatic activity led to lower mitochondrial fragmentation and less cell death than expression of...
Notably, inhibition of DRP1-dependent mitochondrial fission by Mdivi-1 inhibited KLF4 expression and transcriptional activity induced by Ang II.Conclusions: In conclusion, mitochondrial fission involves Ang II-induced VSMC proliferation and migration through KLF4 upregulation, and that Rh1 inhibits VSMC ...
The functional blockage of signaling by Shh siRNA or Gli1 siRNA led to significantly increased expression of mitochondrial fission protein dynamin-like GTPase Drp1. The H2O2 -treated EH cells showed diminished Gli1 and increased Drp1 expression, concurrent with reduced p-Drp1-(serine637). Whereas ...