必应词典为您提供driver-mutation的释义,网络释义: 驱动突变;司机突变;驱动型突变;
Stratton 等将目光聚焦到结肠,他们发现大量的正常结肠上皮细胞中存在多种体细胞突变,而且在中年人中,1% 的结肠样本携带 driver mutation [7]。这些聚焦正常体细胞中突变和 driver mutation 的研究,似乎正在挑战我们对于肿瘤发生最早期事件的认知。如果相当一部分正常细胞中已经携带 driver mutation,但是其中只有部分可以 ...
我们把对癌症发展具有正向作用的突变定义为“driver mutation",其他突变定义为”passage mutation"。因此从大量的mutations中鉴别driver mutation对于癌症的治疗是十分重要的。 See the source image 目前识别driver mutation 的方法大致可以分为两类:1.基于突变频率 2. 基于功能影响评分 基于突变频率的方法最适合于寻找频...
STAT5B, a frequently-occurring oncogenic driver mutation, promotes aggressive T-cell leukemia/lymphoma in patient carriers, although the molecular origins remain unclear. Herein, we emphasize the aggressive nature of STAT5Bin driving T-cell neoplasia upon hematopoietic expression in transgenic mice, ...
In this study, we deeply examined the relationships between major driver mutation subtypes and differential immunophenotypes determined by RNA-sequencing or mIHC in PAAD. According to public data analyses of PAAD cohorts, co-mutant KRAS G12D & TP53 were shown to involve with high Th2 as well...
(TCR) reactive to the recurrent D835Y driver mutation in the FLT3 tyrosine kinase domain (TCRFLT3D/Y). TCRFLT3D/Y-redirected T cells selectively eliminated primary human AML cells harboring the FLT3D835Ymutation in vitro and in vivo. TCRFLT3D/Ycells rejected both CD34+and CD34−AML in ...
AThe proportion of tumors harboring each driver mutation in localized prostate cancer or mCRPC (‘Observed Δ Proportion’), as described. Dot size indicates −log10q-value; dot color indicates driver mutation type. Specific genes of interest are labeled.BComparison of driver gene mutation prevalen...
One way of addressing this question is through inspection of somatic mutations in DNA of cancer samples from a cohort of patients and detection of patterns that differentiate driver from passenger mutations. We propose QuaDMutEx, a method that incorporates three novel elements: a new gene set ...
e13003 Background: Many cancers could be driven by germline mutation exampled as BRCA1/2 in breast or ovarian cancer. However, the candidate predisposition variants for Chinese lung cancer are largely unknown. Methods: We reviewed 1797 Chinese lung cancer patients with paired tumor-normal samples ...
| 血液肿瘤,一类常见恶性肿瘤,与其他实体恶性肿瘤不同,髓系血液恶性肿瘤几乎见于各个年龄段,具明显可遗传性。尽管近几十年对血液恶性肿瘤发生的体细胞驱动突变(Somatic Driver Mutation)的发现和相关致病机理已经有了较完整的研究,但对可遗传的胚系突变(Germline Mutation)在血液肿瘤发生中的作用理解非常有限。