STAT5B, a frequently-occurring oncogenic driver mutation, promotes aggressive T-cell leukemia/lymphoma in patient carriers, although the molecular origins remain unclear. Herein, we emphasize the aggressive nat
必应词典为您提供driver-mutation的释义,网络释义: 驱动突变;司机突变;驱动型突变;
Stratton 等将目光聚焦到结肠,他们发现大量的正常结肠上皮细胞中存在多种体细胞突变,而且在中年人中,1% 的结肠样本携带 driver mutation [7]。这些聚焦正常体细胞中突变和 driver mutation 的研究,似乎正在挑战我们对于肿瘤发生最早期事件的认知。如果相当一部分正常细胞中已经携带 driver mutation,但是其中只有部分可以 ...
但如果对比分析结肠腺癌/肉瘤以及正常结肠细胞中的driver mutation,发现在结肠癌中常见的APC、KRAS、TP53基因的突变占了碱基替换和插入突变的56%,而在正常隐窝中相对稀少,这提示APC、KRAS、TP53等基因的突变赋予了正常细胞转化为结肠腺癌更高的可能性。总体而言,文章思路清晰,先检测了整体的体细胞突变,按照突变的频率,...
Driver 和 passenger 在这里代表“驱动”突变和 “携带”突变 比如在肿瘤研究中 driver mutation就是对肿瘤发生发展有贡献的突变，他们是司机，导致了肿瘤发生； 而passenger mutation可以理解为伴随肿瘤发生的一系列突变，他们是乘客，伴随发生而已，并不是肿瘤发生的原因 ...
Fundamental immune–oncogenicity trade-offs define driver mutation fitness David Hoyos, Roberta Zappasodi, Isabell Schulze, Zachary Sethna, Kelvin César de Andrade, Dean F. Bajorin, Chaitanya Bandlamudi, Margaret K. Callahan, Samuel A. Funt, Sine R. Hadrup, Jeppe S. Holm, Jo...
突变（ "passenger" mutations），这种突变的基因被称为passenger gene；而驱动突变（driver mutation）能...
Nonhypermutated tumors reverse the germline mutation bias and have consistent spectra across tissues. These spectra changes carry the signature of hypoxia, and they facilitate positive selection in cancer genes. Hypermutated and nonhypermutated tumors thus acquire driver mutations differently: hypermutated ...
As alterations in epigenetic regulators frequently lead to genomic instability, DNMT3A mutation may further drive progression of the disease itself (Wakita et al., 2013). Further, recent experimental work has demonstrated that DNMT3A mutations at R882 are only found in major clones, suggesting this...
The trinucleotide context of regions and mutations is considered for mutation rate analysis. We performed a driver discovery of cis-regulatory modules (CRMs) and found frequently mutated regulatory elements (FMREs). FMREs were associated with target genes using long-range chromatin interactions. Tumor...