驱动基因。在恶性肿瘤里面有很多突变的基因，其中一部分直接和肿瘤的发生发展有关，这部分基因定义为驱动基因，如肺癌中的EGFR，乳腺癌胃癌中的HER2基因等等 这是生物病理学的一个名词。祝你好运
癌症是以基因突变导致细胞异常和失控生长为特征的一系列疾病。驱动基因(Cancer Driver Gene, CDG)是指对肿瘤进展有重大影响的基因。根据在癌症进展中的作用,驱动基因可分为两大类:原癌基因(Oncogenes)和抑癌基因(Tumor Suppressor Genes)。癌基因成瘾(oncogene addiction)是指某些肿瘤维持其恶性生物学表型依赖于某个或...
This chapter focuses primarily on mutations in driver genes that are predictive markers in current clinical trials and might be useful for early diagnosis, if they may be detected with minimally invasive technologies. This will entail, first, a broad listing of predictive markers, followed by a ...
Comment on Nat Genet. 2014 Aug;46(8):837-43.doi:10.1038/nrclinonc.2014.121WoodNatalie J.Nature Reviews Clinical OncologyWood NJ. Genetics: driver genes are mutated early in the course of esophageal adenocarcinoma. Nat Rev Clin Oncol. 2014;11:439....
Genomic characteristics of driver genes in Chinese patients with non‐small cell lung cancerDriver genenext‐generation sequencingnon‐small cell lung cancerBackground The aim of this study was to determine the demographic profile of driver gene alterations, especially low‐frequency gene alterations in ...
RESEARCH HIGHLIGHTS Nature Reviews Genetics | AOP, published online 9 December 2014; doi:10.1038/nrg3875 Stockbyte Royalty Free Photos CANCER GENETICS Leveraging functional data for driver genes A continuously expanding list of genes are proposed as putative driver genes in various cancers, but ...
“This is the first time that three-dimensional protein features, such as PPIs, have been used to identify driver genes across large cancer datasets,” explained lead author Eduard Porta-Pardo, Ph.D., postdoctoral fellow at SBP. “We found 71 interfaces in proteins previously unrecognized as ca...
A key challenge in the analysis of cancer genomes is the identification of driver genes from the vast number of mutations present in a cohort of patients. DOTS-Finder is a new tool that allows the detection of driver genes through the sequential application of functional and frequentist approaches...
Objective: We propose an effective method that combines the two characteristics of genes, cooccurring mutations and the coordinated regulation of proliferation genes, to explore cooperation driver genes. Methods: This study is divided into three stages: (1) constructing a binary gene mutation matrix;...
The KM plotter analysis indicated that the out of all genes 5 genes are statistically significant. The cBioPortal platform was further used to investigate the frequency of genetic mutations across the board and how they affected the survival of the patients. Maximum mutation was reported by ELAVL2...