Additionally, tumor-associated microglia/macrophages number, function and polarization are heavily influenced by specific driver-gene mutation combinations. Furthermore, we demonstrate that efficacy of checkpoint blockade therapy using anti PD-1 as a single agent or in combination with anti CTLA-4 is ...
这种突变的基因被称为passenger gene；而驱动突变（driver mutation）能提供所在细胞的生长优势，是肿瘤发生...
AThe proportion of tumors harboring each driver mutation in localized prostate cancer or mCRPC (‘Observed Δ Proportion’), as described. Dot size indicates −log10q-value; dot color indicates driver mutation type. Specific genes of interest are labeled.BComparison of driver gene mutation prevalen...
图1:乘客突变(passenger mutation)和驱动突变(driver mutation)。肿瘤测序显示,转化细胞的基因结构以大量突变的积累为特征。然而,在这些基因变化中,有一小部分驱动突变具有积极的致癌特性,其余的乘客突变是惰性变化,在肿瘤发生过程中既不被选择也不被对抗。区分驱动突变和客体突变是一项关键的研究目标,因为前者是潜在的治...
S. Why are there hotspot mutations in the TP53 gene in human cancers? Cell Death Differ. 25, 154–160 (2018). Article CAS Google Scholar Petitjean, A. et al. Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the ...
To effectively identify driver genes, we adopted a semi-local centrality measure and gene mutation effect function to assess the effect of gene mutations on changes in gene expression patterns. Firstly, we calculated the mutation score for each gene. Secondly, we identified differentially expressed ge...
Because the frequency of several gene mutations differed between younger (<60 years) and older (≥60 years) patients, and treatment intensity was higher in younger patients, we also tested for interactions between each individual gene mutation and age. In a multivariate model for OS (Table 2),...
The researchers used cancer mutation and protein structure databases to identify mutations in patient tumors that alter normal protein-protein interaction (PPI) interfaces—identifying more than 100 novel cancer driver genes that may help explain how tumors that are driven by the same gene often lead...
原文献利用tcga的乳腺癌卵巢癌等geneexpressiondata和codingregionmutationdata并结合cancergenecensus数据库收录的已知癌症相关基因发现dawnrank算法可以较好的分析出drivergene并且结果优于其它同类算法如drivernetparadigmshift 科研时间:利用DawnRank挖掘疾病样本drivergene 一、流程介绍 2014年Genome Medicine杂志上发表了新算法...
DNA methylation at gene promoter CGIs potently blocks the initiation of transcription, whereas methylation within CpG-poor gene bodies may actually facilitate elongation and influence patterns of alternate splicing. In addition, DNA methylation is frequently found in repeat-rich areas of the genome and...