Driver 和 passenger 在这里代表“驱动”突变和 “携带”突变 比如在肿瘤研究中 driver mutation就是对肿瘤发生发展有贡献的突变，他们是司机，导致了肿瘤发生； 而passenger mutation可以理解为伴随肿瘤发生的一系列突变，他们是乘客，伴随发生而已，并不是肿瘤发生的原因 ...
图1:乘客突变(passenger mutation)和驱动突变(driver mutation)。肿瘤测序显示,转化细胞的基因结构以大量突变的积累为特征。然而,在这些基因变化中,有一小部分驱动突变具有积极的致癌特性,其余的乘客突变是惰性变化,在肿瘤发生过程中既不被选择也不被对抗。区分驱动突变和客体突变是一项关键的研究目标,因为前者是潜在的治...
这种突变的基因被称为passenger gene ；而驱动突变（driver mutation）能提供所在细胞的生长优势，是肿瘤发...
What is this driver/passenger mutation model in CLL? What role does it play in aggressive behavior or treatment resistance? These issues are addressed in this chapter.doi:10.1007/978-3-319-70603-0_5Prabhjot Kaur
“passenger” mutations, which comprise the majority of mutations identified, represent genetic events that have no direct or indirect effect on the selective growth advantage of the cell in which it occurred (Stratton et al.,2009; Vogelstein et al.,2013). Candidate epigenetic driver genes have ...
Cancer genomics demonstrates that these few driver mutations occur alongside thousands of random passenger mutations--a natural consequence of cancer's elevated mutation rate. Some passengers are deleterious to cancer cells, yet have been largely ignored in cancer research. In population genetics, ...
Computational driver discovery is essential to distinguish driver from passenger mutations in the coding and non-coding regions of whole cancer genomes. Here we report DriverPower, a new framework for accurately identifying both types of driver mutation by combining mutational burden and functional impact...
Tug-of-war between driver and passenger mutations in cancer and other adaptive processes Cancer progression is an example of a rapid adaptive process where evolving new traits is essential for survival and requires a high mutation rate. Precanc......
Recent studies on mutations in cancer genomes have distinguished driver mutations from passenger mutations, which occur as byproducts of cancer development. The cancer genome atlas (TCGA) project identified 299 genes and 24 pathways/biological processes
Driver mutations are essential for the manifestation of cancer characteristics, whereas passenger mutations, which are random mutations occurring in the background, do not contribute to tumor development and arise during DNA replication [2]. Next-generation sequencing (NGS) technology has revolutionized ...