Differential response for amyloid clearance in APP Tg2576 mice and APP/PS1 double knockin mice following intracranial LPSBackground: Amyloid precursor protein (APP) is an acute phase reactant that increases in response to inflammation or acute brain injury (Siman et al, 1989, Neuron 3:275). ...
Preselection-Tcrb repertoire is impaired and antigen-specific IgG antibody responses following immunization are blunted in Ser389GSK3b knockin mice. Thus, GSK3b emerges as an important modulator of the adaptive immune response. 1 Department of Medicine/Immunobiology, University of Vermont, Burlington, ...