...发症发生风险明显降低,提示可能存在一种所谓的剂量—反应关系(dose-response relation),即并发症的发生与EN的摄入 … www.39kf.com|基于2个网页 3. 剂量效应 ...较未暴露之参考族群来得差,不过在暴露族群内并未发现剂量效应(dose-response relation)。
Dose-response relationship, effect on an organism or, more specifically, on the risk of a defined outcome produced by a given amount of an agent or a level of exposure. A dose-response relationship is one in which increasing levels of exposure are associ
A dose–response relationship refers to the relation between the likelihood and severity of resulting adverse health effects from a given dose of agent and condition of exposure. From:Encyclopedia of Toxicology (Third Edition),2014 Discover other topics ...
DOSE similartodrug‘seffectiviness,drug’stoxicitye.g.lethality(mortality)alsoshowsdoseresponserelationship,typicalSshapecurve.LD50(thedosageofasubstancethatkills50%oftheanimalsoverasetperiodoftimefollowinganacuteexposure).Therapeuticindex(TI)=LD50/ED50ThelowerTI,thesmallerthemarginofsafety,e.g.digoxin,2....
One of the most powerful tools in the analysis of toxicological events is the description of the intensity of the exposure in terms of dose, dose rate, or concentration for a specified duration of exposure in relation to the frequency or intensity of the observed responses. Dose-response ...
•Exposuresarequantifiedinrelationtothe media. –mg/Linwater. –mg/kginfood. –mg/m 3 inair. •Variationinunits common(ppm,ppb). FoodToxicology 6 KeyConcepts •Dosage-responsemathematicalrelationship (positiveslope). •Causalrelationship. ...
This chapter describes a series of microbial dose-response models used to model the probability of infection in relation to the ingested dose. The advantages and limitations of different data sources used to estimate dose-response relationships, and the implications of dose-response factors for risk-...
Methods We developed a simple framework to integrate the a priori dose-response relation for SARS-CoV based on mice experiments, the recent data on infection risk from a meta-analysis and the respiratory virus shedding in exhaled breath, to shed light on the dose-response relation for human. ...
Czeisler, Dose-response relation- ships for resetting of human circadian clock by light, Nature 379 (6565) (1996) 540-542, http://dx.doi.org/10.1038/379540a0 (PubMed PMID: 8596632).Boivin DB, Duffy JF, Kronauer RE, Czeisler CA 1996 Dose-re- sponse relationships for resetting of ...
et al. Dose–response relationships between urinary cobalt concentrations and obesity, insulin resistance, and metabolic-related disorders in the general population. Environ Sci Pollut Res 29, 29682–29688 (2022). https://doi.org/10.1007/s11356-021-17861-0 Download citation Received10 September ...