The biomedical community made a fundamental error on the nature of the dose-response relationship early in the 20th century and has perpetuated this error to the present. The error was the byproduct of the conflict between homeopathy and traditional medi
Relationship of topical dose and percutaneous absorption on rhesus monkey and man. J Invest Dermatol. 1976;67:518–520. CrossRef Scheuplein RJ, Ross LW. Mechanism of percutaneous absorption. V. Percutaneous absorption of solvent-deposited solids. J Invest Dermatol. 1974;62:353–360. CrossRef ...
Molecular imaging and molecular profiling for head and neck, lung and rectal cancer MRT: application in dose-painting and response prediction. To date, no great interest has been shown in the clinical implementation of recent Image-guided radiation therapy (IGRT) modalities in rectal cancer since ...
Efficacy. No patients who received AZD0424 achieved a complete response or partial response. A total of seven patients (17.1%) had a best response of SD (lasting at least 6 weeks), of whom five achieved SD lasting 412 weeks. Twenty-two patients had a best response of PD and 12 patients...
Miller WR, Telford J, Dixon JM, Hawkins RA: Androgen receptor activity in human breast cancer and its relationship with oestrogen and progestagen receptor activity. Eur J Cancer Clin Oncol 21: 539–542, 1985 CrossRef Lippman ME, Huff K: A demonstration of androgen and estrogen receptors in...
A dose–response relationship was observed between aerobic exercise intensity and improvement in EF. A 2 metabolic equivalents (MET) increase in absolute exercise intensity or a 10 % increase in relative exercise intensity resulted in a 1 % unit improvement in FMD. There was a positive ...
With regard to soft tissue sarcomas, a dose-response relationship is suggested for Doxorubicin [6, 7] or his analogue Epidoxorubicin [8, 9], although with an increased cardiotoxicity. Similarly, in a review performed on the efficacy of Ifosfamide (a new effective drug more recently introduced ...
All-trans retinoic acid pharmacokinetics and bioavailability in acute promyelocytic leukemia: intracellular concentrations and biological response relationship. J Clin Oncol 1995; 13(10): 2517–23 Adamson PC, Boylan JF, Balis FM, et al. Time course of induction of metabolism of all-trans-retinoic ...
Correlation analysis showed that the relationship between the actions of ANF and the increases in plasma cyclic GMP levels is loose and cannot predict the hemodynamic or renal effects of exogenous ANF in a given patient. Although the behavior of plasma cyclic GMP levels fails to predict the ...
A number of researchers have dismissed the increases in infant leukemia following the Chernobyl fallout as causally due to radiation exposure on the basis that the dose response relationship does not increase monotonically e.g., [6,8]. This argument needs to be addressed. ...