Conolly, Dose-response relationship and extrapolation in toxicology. Mechanistic and statistical considerations, in: F.X. Reichl, M. Schwenk (Eds.), Regulatory Toxicology, Springer-Verlag, Berlin, Hei- delberg, 2014. http://dx.doi.org/10.1007/978-3-642-35374-1_72....
In subject area: Pharmacology, Toxicology and Pharmaceutical Science A dose–response relationship refers to the relation between the likelihood and severity of resulting adverse health effects from a given dose of agent and condition of exposure. ...
That is, it is likely that each organ system will display a unique dose–response relationship. However, the reality of the cancer bioassay is that because it is imposed on all tissues simultaneously, one would predict a diverse array of organ-specific dose responses. In addition, each ...
Dose-response relationships in chemical carcinogenesis: superposition of different mechanisms of action, resulting in linear-nonlinear curves, practical thresholds,... WK Lutz - 《Mutation Research/fundamental & Molecular Mechanisms of Mutagenesis》 被引量: 177发表: 1998年 Dose-response relationship and ...
The term “NMDR” describes a dose-response relationship characterized by a curve whose slope changes direction within the range of tested doses. Non-monotonicity represents a challenge to fundamental concepts in toxicology and risk assessment. Indeed, environmental risk assessment approaches used by re...
Getting the dose–response wrong: why hormesis became marginalized and the threshold model accepted During the early decades of the twentieth century consensus emerged that the most fundamental dose–response relationship was the threshold model, upon which ... EJ Calabrese - 《Archives of Toxicology》...
CONCLUSIONS There is a dose-response relationship between cadmium exposure and renal dysfunction in general population. The study suggests that the limit of lifetime cadmium uptake should be lower than 100 mg, and the urinary NAG could be used as an early indicator of renal injury induced by ...
toxicology and risk assessment professions is to base regulatory strategies on the interaction of these EACs with the fundamental control mechanisms which regulate responses throughout the body and to determine the extent to which these interactions create specific dose–response behaviors in the living ...
Dose-response relationships for incidence are based on quantal response measures. A defined effect is either present or not present in an individual. The dose-incidence curve therefore reflects differences in individual susceptibility (the "tolerance distribution"). At low dose, only the more susceptib...
In 2003, the International Union of Pure and Applied Chemistry issued a glossary of terms that included definitions of the dose-effect and dose-response re... DAPHNE B. MOFFETT,HISHAM A. EL-MASRI,BRUCE A. FOWLER - 《Handbook on the Toxicology of Metals》 被引量: 5发表: 2007年 Potential...