Controversy on toxicological dose–response relationships and extrapolation of an incidence to low dose can be the consequence of misleading data presentation, diverging mechanistic understanding, or lack of differentiation between a continuous response variable, such as any concentration of a biomarker, ...
Figure 1.19.Typical sigmoid S-shaped curve showing quantal dose–response relationship. The response may be effective dose or morality. Explanation: In toxicology, quantal dose–response relationship is extensively used for the calculation of lethal dose (LD) because in it we observe only ...
Also known as: dose-response curve Written by Sydney Pettygrove Assistant Professor, Epidemiology and Biostatistics Department, The University of Arizona. Her contributions to SAGE Publications’Encyclopedia of Epidemiology(2008) formed the basis of her contributions... ...
Learn the definition of dose response curve, and discover its equation and phases. Understand effective vs. lethal doses, and see dose-response...
dose-effect curve (dose-response curve) a graphic representation of the effect caused by an agent (such as a drug or radiation) plotted against the dose, showing the relationship of the effect to changes in the dose. growth curve the curve obtained by plotting increase in size or numbers ag...
the steepness of the slope indicates that incremental changes in dose quickly elevate the degree of toxic response. This fact could be important in the event of anaccidental poisoningvia household or occupational exposure (seeOccupational Toxicology). Furthermore, these values assume that the curve it...
The outcome of dose-response assessment is a value which, when combined with the exposure estimate, will allow an estimation of health risk. Key tasks in dose-response assessment are the compilation of dose-response data from animal and human toxicology studies, selection of the most sensitive ...
The shape of the dose-cancer incidence curve observed in an animal bioassay for carcinogenicity of a chemical is the result of a superposition of various m... WK Lutz - 《Human & Experimental Toxicology》 被引量: 24发表: 1999年 Dose–response relationships in chemical carcinogenesis: superpositio...
A few landmarks in the development of dose response in toxicology are presented, with an explanation of why dose should only be considered on a logarithmic scale. Examples are shown, illustrating that the current practice of labeling dose-response curves for carcinogenesis as supralinear, linear ...
A dose escalating toxicology assessment of ELP-VEGF was performed by administering a bolus intravenous injection at doses ranging from 0.1 to 200 mg/kg in Sprague Dawley (SD) rats. Blood pressure, body weight, and glomerular filtration rate (GFR) were quantified longitudinally, and terminal blood...