In search of evidence for the dopamine hypothesis of schizophrenia, this review focuses on studies of patients with schizophrenia. The review is com-posed of two parts: the fi rst serves as a short reminder of the anatomy and function of the dopamine system, and the second guides the reader...
The dysregulation hypothesis of schizophrenia should be a useful reformulation. Rather than conceptualizing a static hyperdopaminergic state, schizophrenia might be better understood as a reflection of a relative failure of dopaminergic regulation. Evidence for such dysregulation is examined and possible ...
In a pharmacological study and an independent neuroimaging study, we tested the hypothesis that the neural reward system encodes the value of sharing money with others more strongly in women than in men. In the pharmacological study, we reduced receptor type-specific actions of dopamine, a ...
Within schizophrenia, striatal dopamine dysfunction has been proposed to underlie the development of psychosis. The Aberrant Salience hypothesis provides an explanatory model based on empirical findings to explain how psychotic symptoms may arise from striatal hyperdopaminergia, whereby multiple risk factors...
The dopamine hypothesis of schizophrenia: focus on the dopamine receptor Am. J. Psychiatry, 133 (1976), pp. 197-202 View in ScopusGoogle Scholar Ugi et al., 2004 S. Ugi, T. Imamura, H. Maegawa, K. Egawa, T. Yoshizaki, K. Shi, T. Obata, Y. Ebina, A. Kashiwagi, J.M. Olef...
The dopamine hypothesis of schizophrenia: version III—the final common pathway. Schizophr Bull 2009; 35: 549–562. 12 Koob GF, Bloom FE. Cellular and molecular mechanisms of drug dependence. Science 1988; 242: 715–723. 13 Hietala J, Syvälahti E, Vuorio K, Räkköläinen V, ...
The evidence reviewed suggests that schizophrenic patients, especially those who benefit from neuroleptics, have a hyperactivity of the nigrostriatal dopamine system in the brain. Further test of areas of this hypothesis should elucidate some of the problems in schizophrenia. There is a lack of knowle...
Consistent with this hypothesis is the finding that showed in preparations in which NO infusion inhibits dopamine efflux, the inhibition was blocked or reversed by coperfusion of an antioxidant or ONOO− scavenger (Buyukuysal, 1997; Trabace and Kendrick, 2000). Additionally, Lin et al. (1995...
- 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 197发表: 2011年 [Glutamatergic hypothesis of schizophrenia]. Finaly the paper discusses the interaction between the dopaminergic and the glutamatergic systems; in special how hyperdopaminergic state found in...
To test this hypothesis, we assessed how manipulation of dopaminergic neurotransmission in the NAc affects social play behavior in rats. Dopamine signaling in the NAc occurs through D1 and D2 receptors that are for the most part localized on output neurons with distinct anatomical and cytochemical ...