The original dopamine hypothesis of schizophrenia posits that psychosis is associated with a hyperactive dopamine transmission. This hypothesis has been revised through the years to account for the cognitive and negative symptoms that are increasingly recognized as the core features of schizophrenia. The ...
The dopamine (DA) hypothesis of schizophrenia manifests in two guises, as an error in DA economy or in DA receptor response. Amphetamine psychosis is the closest human model of schizophrenia, supposedly mediated via DA release from its binding sites, yet L-dopa, which floods the brain with ...
by Abi-Dargham A, Rodenhiser J, Printz D, Zea-Ponce Y, Gil R, Kegeles LS, Weiss R, Cooper TB, Mann JJ, Van Heertum RL, Gorman JM, Laruelle M Departments of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. aadar@neuron.cpmc....
hypothesis is a theory that proposes a biological cause of schizophrenia. This is the oldest theory about the cause of schizophrenia and was first presented in the 1960s. It suggests that schizophrenia is caused by too much DA transmission in the brain. Pharmacological evidence exists for this th...
dopamine hypothesis[′dōp·ə‚mēn hī‚päth·ə·səs] (medicine) A theory that explains the pathogenesis of schizophrenia and other psychotic states as due to excesses in dopamine activity in various brain areas. McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyrigh...
Frontiers | Dopamine receptors and the dopamine hypothesis of schizophrenia. The discovery of neuroleptic drugs in 1952 provided a new strategy for seeking a biological basis of schizophrenia. This entailed a search for a primary si... P Seeman 被引量: 1757发表: 0年 The Role of Dopamine in ...
What do the results of Ripke's study imply for the dopamine hypothesis? Some of the genes identified code for production of other neurotransmitters so, although dopamine is likely to be one important factor, so are other NTs What is the name of the NT that Moghaddam & Javitt have found ...
1 Understanding its neurobiology is critical for future rational drug discovery.2,3 The dopamine hypothesis of schizophrenia was first proposed more than 30 years ago on the basis of indirect evidence. It received support from studies of postmortem brain tissue that found increased striatal D2/3 ...
Dopamine neurotransmission is thought to play a key role in the clinical development and manifestation of schizophrenia. The ‘dopamine hypothesis’ for schizophrenia was developed in the 1960s, based on the fact that early anti-psychotics, such as haloperidol and chlorpromazine, were strong D2R antag...
Schizophrenia: Reconciliation of the dopamine, prostaglandin, and opioid concepts and the role of... MD Altschule,JT Bagnara - 《Quarterly Review of Biology》 被引量: 35发表: 1975年 Frontiers of Bioorganic Chemistry and Molecular Biology Frontiers of Pineal Physiology. In: Horrobin, D.F., ed...