Link between D1 and D2 Dopamine receptors is reduced in schizophrenia and Huntington diseased braindoi:10.1073/pnas.86.24.10156Philip SeemanH B NiznikH C GuanCarla Ulpian
Schizophrenia is a most disabling psychiatric disorder characterized by a myriad of symptoms. While the delusions and hallucinations are the most iconic symptoms of schizophrenia, patients also exhibit negative and cognitive symptoms. It is thought that
Ball-and-stick model of the dopamine molecule, a neurotransmitter that affects the brain's reward and pleasure centers. Credit: Jynto/Wikipedia Researchers at Columbia University Irving Medical Center (CUIMC) and New York State Psychiatric Institute (NYSPI) found that people with schizophrenia who e...
Creativity often goes hand-in-hand with mental illness, such as schizophrenia. Now scientists think they know why: The brain responds differently to the "feel good" chemical dopamine in both schizophrenics and the highly creative, a new study suggests. The results showed similarities between the ...
Davis, J. M. (1978). Dopamine theory of schizophrenia: A twofactor theory. In L. C. Wynne, R. L. Cromwell, & S. Matthysse (Eds.),The nature of schizophrenia: New approaches to research and treatment(pp. 105–115). New York: Wiley. ...
dopamine, serotonin, opioid peptides, glutamate and γ-aminobutyric acid (GABA), which are involved in positive and negative reinforcement processes that participate in the motivation for drug seeking and maintenance of alcohol use after the development of dependence.2Pharmacological approaches that have...
Neuropsychological studies have revealed several well-documented differences in executive function and motivation domains between patients with ADHD and healthy control patients [39]. Strong evidence points to dopamine system dysfunction at the onset of ADHD [40]. According to the dopamine theory, childre...
These abnormal- ities were already present at the prepubescent stage of devel- opment and persisted into adulthood. Long-lasting alterations in apomorphine-induced motor activity were also exhibited, which suggested reductions in dopamine receptor sensitivity and/or in the cellular and motor network ...
between measures of executive functions and handgrip strength) has not been extensively studied. Again, an early recognition of adults being at high risk of developing dementia (e.g., older adults with aMCI and executive dysfunction) is essential to initiate appropriate interventions, and thus the...
moods. This class of neurtransmitters includes dopamine, norepinephrine, epinephrine and serotonin – and these affect appetite as well. A shortage can lead to depression and too much can cause ‘high’ moods and – in the extreme – mania and schizophrenia. Food also affects our moods, she ...