schizophrenia remains one of the leading causes of global disease burden in adults despite more than 50 years of drug development. understanding its neurobiology is critical for future rational drug discovery. the dopamine hypothesis of schizophrenia was first proposed more than 30 years ago on the ...
Sensitivity analyses were conducted to explore the consistency of effects and the effect of clinical and imaging variables. Data Synthesis There was a highly significant elevation (P < .001) in presynaptic dopaminergic function in schizophrenia with a large effect size (Cohen d = 0.79). There was...
Sensitivity analyses were conducted to explore the consistency of effects and the effect of clinical and imaging variables. DATA SYNTHESIS: There was a highly significant elevation (P.<001) in presynaptic dopaminergic function in schizophrenia with a large effect size (Cohen d=0.79). There was no...
However, research-based evidence suggests that the intravenous (IV) application of heroin under medical supervision may have untoward side effects. Recent studies have shown that heroin injections produce transient, but significant decreases in systemic and cortical oxygenation most likely secondary to ...
Central dopaminergic systems are known to be implicated in the pathophysiology of schizophrenia and recent in vivo dopamine receptor imaging studies have focused on the measurement of extrastriatal dopamine receptor. However, there are only a limited number of ligands that can measure the low-density ...
In healthy individuals, dopamine stimulants such as amphetamine can induce psychotic symptoms26,27and people with schizophrenia are more sensitive to these effects27,28. Studies using positron emission tomography (PET) imaging have shown patients with schizophrenia show increases in subcortical synaptic do...
behavior, and movement. It plays a major role in how we feel pleasure, seek rewards, and stay motivated. Dopamine levels that are too high or too low cause mental and physical conditions like Parkinson’s disease andschizophrenia. Talk to your doctor if you are concerned about your dopamine ...
D1 receptors are responsible for majority of peripheral dopamine effects; in the brain they modulate activity of limbic system. Symptoms of schizophrenia are produced by increased activation of D2 and D4 receptors. On the other hand, Parkinson's syndrome could be induced by D2 receptors blockade...
80. This is pertinent given the implication of reward-based reversal-learning deficits in schizophrenia81. Conversely, the finding that methylphenidate boosts unsigned surprise-related striatal signals and stimulus-selectivity in the visual cortex, while also reducing the impact of reward versus punishment...
On reflection, however, it becomes apparent that the term memory applies to many different facets of an organism's ability to conserve and utilize the effects of its experi... DL Schacter,M Moscovitch - Springer US 被引量: 272发表: 1984年 Increased lifetime reproductive success for Siberian ...