The dopamine (DA) hypothesis is a theory that proposes a biological cause of schizophrenia. This is the oldest theory about the cause of schizophrenia and was first presented in the 1960s. It suggests that schizophrenia is caused by too much DA transmission in the brain. Pharmacological evidence...
The Division of Clinical Psychology of the British Psychological Society published a paper titled Understanding Psychosis and Schizophrenia.The central theme of the paper is that the condition known as psychosis is better understood as a response to adverse life events rather than as a symptom of ...
The idea behind this hypothesis is that when it comes to schizophrenia, there’s a problem with the balance or regulation of dopamine in a person’s system. Dopamine is a chemical messenger in the brain that helps with various functions, such as motivation, pleasure, and energy. This hypothes...
KS Kendler,KF Schaffner - 《Philosophy Psychiatry & Psychology》 被引量: 55发表: 2011年 Dopamine receptor excess and mouse madness. The dopamine hypothesis of schizophrenia is based on evidence that the major antipsychotic drugs act by blocking dopamine D2 receptors and that dopamine-re... SH ...
Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications. Acta Psychiatr Scand 112: 330–350. Article CAS PubMed Google Scholar Robinson TE, Berridge KC (2000). The psychology and neurobiology of addiction: an incentive-sensitization view. Addiction...
2Department of Psychiatry, Division of Brain and Therapeutics, University of Toronto, Toronto, ON, Canada; 3Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, ON, Canada A number of addictions have been linked with decreased striatal dopamine (DA) receptor availability and DA ...
Bipolar affective disorder is a common neuropsychiatric disorder. Although its neurobiological underpinnings are incompletely understood, the dopamine hypothesis has been a key theory of the pathophysiology of both manic and depressive phases of the illn
A motivational learning hypothesis of the role of mesolimbic dopamine in compulsive drug use J. Psychopharmacol., 12 (1998), pp. 54-67 Google Scholar 54 G. Di Chiara, A. Imperato Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely ...
One implication of this hypothesis is that appetitive motivation can induce cognitive improvement or impairment depending on task demands. 展开 关键词: dopamine motivation cognition striatum flexibility prefrontal cortex reward Parkinson's disease DOI: 10.3389/fpsyg.2011.00163 被引量: 191 ...
In this controlled study, we used a recently developed personality questionnaire, Cloningers's Tridimensional Personality Questionnaire, to test the hypothesis that these personality traits are behavioural manifestations of damaged dopaminergic pleasure and reward systems. We found significantly less (p < ...