1-Sentence-Summary:Dopamine Nationtalks about the importance of living a balanced life in relation to all the pleasure and stimuli we’re surrounded with on a daily basis, such as drugs, devices, porn, gambling facilities, showing us how to avoid becoming dopamine addicts by restricting our acc...
—— 引自章节:139 第 7 章 在痛苦端施加压力 <前页123456789后页> >我来写笔记 >Dopamine Nation 作者:Anna Lembke 副标题:Finding Balance in the Age of Indulgence isbn:152474672X 书名:Dopamine Nation 页数:304 出版社:Dutton 出版年:2021-8-24 装帧:Hardcover...
Peptide digests were loaded onto an in-house packed ReproSil-Pur 120 C18-AQ analytical column (75 µm id × 40 cm, 1.9 µm particle size; Dr Maisch, Ammerbuch, Germany) regulated to 60 °C using a PRSO-V2 Sonation column oven (Sonation, Baden-Wuerttemberg, Germany). A ...
The lysine residues undergo many post-translational modifications, including ubiqui- tination, SUMOylation and acetylation, which are vital for cell survival and proliferation [70]. The conjugation of DOPAL to lysine residues interferes with many cellular events and down-regulates cell viability, as...
Topiramate does not alter nicotine or cocaine discrimi- nation in rats. Behav Pharmacol 19: 13–20. Le Foll B, Wertheim C, Goldberg SR (2007). High reinforcing efficacy of nicotine in non-human primates. PLoS ONE 2: e230. Lerman C, Caporaso N, Main D, Audrain J, Boyd NR, Bowman ...
Mendez IA, Simon NW, Hart N, Mitchell MR, Nation JR, Wellman PJ et al (2010). Self-administered cocaine causes long-lasting increases in impulsive choice in a delay discounting task. Behav Neurosci 124: 470–477. Mitchell MR, Vokes CM, Blankenship AL, Simon NW, Setlow B (2011). ...
The method for determi- nation of dialysate ACh, without addition of a cholinester- ase inhibitor, has been described previously (Ichikawa et al, 2002b). Glutamate and GABA analysis. The stock-derivatizing agent OPA (o-phthalaldehyde, 3.0 mg; Sigma-Aldrich, St Louis, MO) was dissolved in ...
The ratio data (Figure 3f) confirmed a significant treatment effect (H ¼ 14.95, 4, N ¼ 34, Po0.01); however, only the 10.0-mg/kg dose significantly reduced the discri- mination ratio from that in vehicle-treated rats (Po0.05). PD128,907 had no significant effect on total social ...
Process (b) may be performed using conventional methods for the formation of a tertiary amine by means of reductive ammination. For example when, for compounds of formula (IV) R2 is hydrogen, the reaction may be carried out using sodium triacetoxy borohydride in a suitable solvent such as 1...
The concentration of cAMP in each sample was determined with an RIA of acetylated cAMP, modified from that previously described (Harper and Brooker, 1975). lodination of cAMP was performed using a method described previously (Patel and Linden, 1988). Assay buffer was 50 mM sodium acetate buffer...