The aim of this work is to evaluate a model of dopamine receptor function in which the short splice variant of the dopamine D2 receptor, D2S, is thought to be the autoreceptor that inhibits firing of dopamine neurons and dopamine release, and the long splice variant, D2L, is proposed to ...
Striatal Dopamine D2/D3 Receptors Mediate Response Inhibition and Related Activity in Frontostriatal Neural Circuitry in Humans Although striatal dopamine D₂-like receptors have been linked with impulsive behavior and behavioral inhibition in rodents, a role for D₂-like receptor function in fronto...
Sigma-1 receptor function is critical for both the discriminative stimulus and aversive effects of the kappa-opioid receptor agonist U-50488H The present study was undertaken to identify possible similarities between the effects of kappa-opioid receptor agonist, N-methyl-D-aspartate-receptor anta......
Although this seems very complex, the different receptor isoforms may be grouped into sub-families that resemble the D1 (cloned D1, D5) and D2 (cloned D2(short), D2(long), D3, D4) receptors proposed previously. This chapter shows how this grouping in to sub-families can be ...
In addition to the serotonin 5-HT2A receptor (5-HT2AR), the dopamine D2 receptor (D2R) is a key therapeutic target of antipsychotics for the treatment of schizophrenia. The inactive state structures of D2R have been described in complex with the inverse
Cocaine Administration: D1 Dopamine Receptor Function and Dopamine Clearance/Diffusion in Rat Striatum and Nucleus Accumbens NANCY,R.,ZAHNISER,... - 《Annals of the New York Academy of Sciences》 被引量: 1发表: 1992年 Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the ...
PPARγ reprogramming is altered in mice with cell-specific ablation of the dopamine D2 receptor (D2R) in the striatal medium spiny neurons (MSNs) (iMSN-D2RKO). Administration of a specific PPARγ agonist in iMSN-D2RKO mice elicits substantial rescue of cocaine-dependent control of circadian ...
We conclude that D2 receptor alleles may be associated with reproductive success through altered gonadotrophin secretion and that this effect may be independent of ovulatory function. 展开 关键词: anovulation dopamine receptor gene fecunditys polymerase chain reaction 被引量: 16 ...
Positron Emission Tomography (PET) imaging allows the estimation of multiple aspects of dopamine function including dopamine synthesis capacity, dopamine release, and D2/3 receptor binding. Though dopaminergic dysregulation characterizes a number of neuropsychiatric disorders including schizophrenia and addiction...
Chronic treatment with clozapine, unlike haloperidol, does not induce changes in striatal D-2 receptor function in the rat. Biochem Pharmacol 1985;34:2755–63. CAS PubMed Google Scholar Florijn WJ, Tarazi FI, Creese I. Dopamine receptor subtypes: differential regulation after 8 months treatment ...