Dopamine receptors : structure, function, and implication in psychiatric disorders. In: Gorwood P HM, ed. Psychopharmacogenetics. New York: Springer, 2006; 357-93.Sokoloff P,Leriche L,Le Foll B.Dopamine receptors:structure,function and implication in psychiatric disorders. ....
Two distinct categories of dopamine receptors, termed D1 and D2, have been identified on the basis of pharmacological and biochemical criteria. Some of the progress made in our understanding of the subunit structure, function and signal transduction properties of these important membrane proteins are...
Analyses the function and structure of dopamine receptors. Information on receptor subtypes; Where dopamine receptors are most present within the body; Failure of studies to reveal unequivocal evidence for the involvement of one of these receptors in the etiology of various central nervous system disord...
As one of the most successful therapeutic target families, G protein-coupled receptors (GPCRs) have experienced a transformation from random ligand screening to knowledge-driven drug design. We are eye-witnessing tremendous progresses made recently in the understanding of their structure–function relatio...
The D2 dopamine receptor (DRD2) is a therapeutic target for Parkinson’s disease1 and antipsychotic drugs2. DRD2 is activated by the endogenous neurotransmitter dopamine and synthetic agonist drugs such as bromocriptine3, leading to stimulation of Gi and
Unfortunately, many drugs that target DRD2 cause serious and potentially life-threatening side effects due to promiscuous activities against related receptors. Accordingly, a molecular understanding of the structure and function of DRD2 could provide a template for the design of safer and more effective...
G. Dopamine receptors: from structure to function. Physiol. Rev. 78, 189–225 (1998) Article CAS PubMed Google Scholar Creese, I., Burt, D. R. & Snyder, S. H. Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science 192, 481–483 (...
(Table 1) shows that the formation of amyloids may result both in a loss of function of the polypeptide, as described for the yeast prions (Osherovich and Weissman, 2002, True and Lindquist, 2000), or in a gain of function, as in the case of the HET-s prion (Maddelein et al., ...
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G. Dopamine receptors: from structure to function. Physiol. Rev. 78, 189–225 (1998) Article CAS PubMed Google Scholar Creese, I., Burt, D. R. & Snyder, S. H. Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science 192, 481–483 (...