Although this seems very complex, the different receptor isoforms may be grouped into sub-families that resemble the D1 (cloned D1, D5) and D2 (cloned D2(short), D2(long), D3, D4) receptors proposed previously. This chapter shows how this grouping in to sub-families can be ...
Cocaine Administration: D1 Dopamine Receptor Function and Dopamine Clearance/Diffusion in Rat Striatum and Nucleus Accumbens NANCY,R.,ZAHNISER,... - 《Annals of the New York Academy of Sciences》 被引量: 1发表: 1992年 Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the ...
Although striatal dopamine D₂-like receptors have been linked with impulsive behavior and behavioral inhibition in rodents, a role for D₂-like receptor function in frontostriatal circuits mediating inhibitory control in humans has not ... DG Ghahremani,B Lee,CL Robertson,... - 《Journal of...
It is thought that these symptoms arise, at least in part, through a cortical–subcortical imbalance of dopamine function and pharmacological approaches that reduce dopaminergic neurotransmission through dopamine receptor blockade, and in particular through the D2 receptor, have antipsychotic action in ...
Striatal D2-receptor density was determined by in vitro kinetic analysis of [3H]raclopride binding. DAT function was determined using in vitro kinetic analysis of [3H]dopamine uptake, methamphetamine-evoked [3H]dopamine overflow and no-net flux in vivo microdialysis. DAT cell-surface expression wa...
Dopamine Receptors and Dopamine Transporter in Brain Function and Addictive Behaviors: Insights from Targeted Mouse Mutants Recent advances in molecular biology have resulted in a number of genetically manipulated mice with defined changes at dopamine receptor and the dopamine t... J Drago,P Padungchai...
The novel DA1 receptor agonist fenoldopam is claiming a role in the management of hypertension, heart failure, and the preservation of renal function. DA2 receptor agonists are also being evaluated as potential antihypertensive agents. 展开
Trace amine-associated receptor 1 (TAAR1) is an intracellular expressed G-protein-coupled receptor that is widely expressed in major dopaminergic areas and plays a crucial role in modulation of central dopaminergic neurotransmission and function. Pharmacological studies have clarified the roles of dopamin...
The beliefs about trustworthiness are mapped on to probability of positive or negative feedback with an inverse logistic function. Because D2 receptor activity is linked to choice uncertainty and action variability22,25, we also included another parameter called choice precision parameter \(\gamma\) ...
We examined all known coding-sequence DRD4 polymorphisms, some of which clearly have a greater effect on function than the exon 3 VNTR. Heterozygotes for DRD4 exon 1 or exon 3 null mutations either should express approximately one-half the usual amount of D4 dopamine-receptor protein (exon 1...