A prominent example of this histone crosstalk involves H1x specifically altering H3 lysine methylation, in turn altering gene expression of multiple immune related genes [26, 50]. Such immune genes have been well-documented to dictate many aspects of animal behavior, particularly social behaviors [51...
Although the mechanism underlying this inefficacy is unknown, other repair pathways are inactivated by methylation with aging. In this study, we analyzed the implication of NHEJ genes methylation in the increase of translocations with the age. To this aim, we determined the relationship between ...
To large degree, the expression of genes is regulated at the level of transcription initiation mediated by the specific binding of protein transcription factors (TFs) to short DNA sequence motifs located in gene promoter regions, the DNA-sequence region upstream of genes. Employing both experimental ...
Ageing is an inevitable aspect of life and thus successful ageing is an important focus of recent scientific efforts. The biological process of ageing is mediated through the interaction of genes with environmental factors, increasing the body’s susceptibility to insults. Elucidating this process will...
domain of RNA polymerase II, leading to the enhanced elongation of transcription from the viral promoter. For Tat's transcriptional activity, it has recently been reported that Tat is regulated by lysine methylation [25], and that it interacts with a histone chaperone nucleosome assembly protein [...
For example, high histone acetylation is associated with a form of accessible chromatin (euchromatin) that promotes expression of genes within that area (Figure 1). As such, histone acetylation generally has the opposite effect on high DNA methylation (high histone acetylation allows for increased ...
West Nile virus 5’-cap structure is formed by sequential guanine N-7 and ribose 2’-O methylations by nonstructural protein 5. J. Virol. 2006, 80, 8362–8370. [Google Scholar] [CrossRef] [PubMed] Zhou, Y.; Ray, D.; Zhao, Y.; Dong, H.; Ren, S.; Li, Z.; Guo, Y.; ...
significantly suppressed serum androgen concentrations, increased tubule area, Germ cell and Sertoli cell numbers (p< 0.05) relative to those of Sow or Milk groups. Soy formula had no such effects relative to Sow or Milk groups. mRNAseq revealed 103 differentially expressed genes in the M + E2...
Therefore, HOTAIR can be involved in estrogen signaling and in consequence in estrogen-dependent cancer transformation, although the causative relationship between HOTAIR and such cancers cannot be established on the basis of the presence of EREs, as these motifs are common in the human genes. HOT...